Cyproheptadine is a histamine and serotonin antagonist with anticholinergic properties. It has been advocated for control of symptoms in mild-to-moderate serotonin syndrome.
- Adult Dose = 8mg orally with further dosing every 8 hours for 24 hours if a response is observed.
- Therapy should not be required beyond 24 hours unless related to a MAO inhibitor
- Paediatric Dose = not well established. For 7-14 year olds a dosing regimen similar to above is recommended but at 4mg dosing.
- Graudins A, Stearman A, Chan B. Treatment of the serotonin syndrome with cyproheptadine. Journal of Emergency Medicine. 1998; 16(4):615-619.