Eduard Tolosa i Colomer (1900 – 1981) was a Spanish neurologist and neurosurgeon.
Obtaining a medical degree at the age of twenty-one and doctorate at the age of thirty, Tolosa spent his younger years traveling around Europe to refine his skills in the field of neurology and neurosurgery before becoming the director of these fields at various hospitals and educational institutions and collaborating with the likes of Manuel Corachan Llort, the first Catalan neurosurgeon, to pioneer the field of neurosurgery in Spain. Tolosa was a pioneer of stereotactic surgery for the treatment of Parkinson’s disease and brain tumor pathology, being one of the best in Spain at obtaining brain biopsies during his time.
Outside of clinical work, Tolosa was an avid researcher, publishing over 200 articles on topics ranging from tumour pathology to intracranial haematoma treatment. He was also intensely active in establishing societies for his specialties, being a founding member and elected president for the Portuguese Spanish Society of Neurosurgery, Spanish Society of Neurology, Spanish Society of Neurosurgery, and Catalan Association of Neurology and Psychiatry.
The field of medicine was also prominent in Tolosa’s personal life, with him having married the sister of famous neuropsychiatrist Ramon Sarró, and raising a son who would become a prominent neurologist. Tolosa would unfortunately fall victim to Parkinson’s disease, a disease he had treated in others countless times, and would struggle with it for seventeen years before his passing.
- Born 24th October 1900, in Barcelona, Spain
- 1916 – Bachelor’s degree from the Institut Provincial de Barcelona
- 1921 – Doctor of Medicine from Universitat de Barcelona
- 1922 – 1924 – Studied clinical neurology at Lluís Barraquer Roviralta’s electrotherapy and neurology clinic, Hospital de Sant Pau in Barcelona.
- 1930 – Doctor of Philosophy from Universitat Central de Madrid with the thesis Algunas consideraciones sobre el diagnóstico diferencial de la enfermedad de Raynaud.
- 1932 – Director of Neurology at the Polyclinic Institute (now known as Hospital Plató)
- general surgery, Hospital Clínic in Barcelona.
- 1934 – 1939 – Associate Professor of Neurology at Universitat Autònoma de Barcelona.
- 1937 – Supernumerary doctor at the Hospital de l’Esperança in Barcelona.
- 1940 – Director of Neurosurgery at the Municipal Neurological Institute of Barcelona.
- 1944 – 1954 – Neurosurgeon at the Hospital de Sant Pau under Lluís Barraquer i Ferré.
- 1947 – Founding member and president of the Portuguese Spanish Society of Neurosurgery.
- 1948 – Founding member and president of the Spanish Society of Neurology.
- 1949 – Founding member and president of the Spanish Society of Neurosurgery.
- 1955 – 1956 – Director of Neurosurgery at the Municipal Neurological Institute of Barcelona.
- 1956 – 1970 – Director of Neurosurgery, alongside Adolf Ley at Vall d’Hebron Hospital, Barcelona.
- 1975 – Honorary Professor of Neurosurgery at Universitat Autònoma de Barcelona.
- Died 4th December 1981, in Barcelona, Spain
Tolosa-Hunt syndrome (1954, 1961)
Tolosa-Hunt syndrome is a severe unilateral periorbital headache and ophthalmoplegia resulting from a non-caseating granulomatous inflammation of the cavernous sinus and/or superior orbital fissure. Etiology is often idiopathic, but it may be triggered by trauma, aneurysms, or tumors in the area.
In 1954, Tolosa published the case of a 47-year-old man admitted to the Neurological Institute, Barcelona, in 1949. He had experienced three years of chronic left orbital pain but presented with a severe exacerbation of pain extending to the first branch of the trigeminal nerve and progressing into total ophthalmoplegia. Cerebral angiography revealed a uniform narrowing of segment C2 of the carotid siphon rather than the suspected carotid aneurysm. Negative exploratory craniotomy was performed and the patient died three days later. Autopsy revealed the intracavernous portion of the carotid artery was wrapped in granulation tissue, which narrowed the artery without fully obstructing it.
After William Hunt and his co-workers described similar cases in 1961, Tolosa would provide Hunt with four unpublished pathological illustrations of his original case, before publishing a further observation. It wouldn’t be until four years later, in 1966, for the eponym of Tolosa-Hunt to first appear, where Joseph Lawton Smith and David Samuel Rasmussen Taxdal reviewed the literature and suggested the eponym.
- Tolosa E. Primeros pasos de la Neurocirugía en el antiguo hospital de la Santa Cruz bajo el impulso de Luis Barraquer Roviralta. Medicina Clínica. 1950; 15: 383-5.
- Tolosa ES. Periarteritic lesions of the cavernous syphon with clinical features of a carotid infraclinoid syndrome. J Neurol Neurosurg Psychiatry 1954; 17: 300-302 [Tolosa-Hunt syndrome]
- Tolosa E, Fuenmayor P, Llovet J. Syndrome du sinus caverneux. Considérations sur ses formes bénignes et spontanement régressives. Revue d’oto-neuro-ophtalmologie, 1961; 33: 365-368. [Tolosa-Hunt syndrome]
- Tolosa ES, Klawans HL. Meige’s disease: A clinical form of facial convulsion, bilateral and medial. Archives of neurology 1979; 36: 635-637
- Tolosa ES. Clinical features of Meige’s disease (idiopathic orofacial dystonia). Archives of neurology 1981; 38: 147–51.
Despite sharing similar specialities, Tolosa i Colomer is not to be confused with his son, Eduardo Tolosa Sarró, who is a pioneer of research in the field of Parkinson’s disease.
- Bibliography. Eduard Tolosa i Colomer (1900 – 1981). World Cat Identities
- Revista española de oto-neuro-oftalmología y neurocirugía. 1973; 31: 193-195.
- Eduard Tolosa i Colomer. Galeria de Metges Catalans
- Portrait; Tolosa i Colomer, Eduard (1900-1981) Banco de imagenes medicina
- Guardiola E, Baños JE. Eduard Tolosa i Colomer. La síndrome de Tolosa-Hunt. In: Eponímia mèdica catalana II. Cuadernos de la fundación Dr. Antoni Esteve. 2011; 87-89.
- Giménez-Roldán S. Spanish eponyms in clinical neurology. Neurosciences and History 2017; 5(1): 1-19
the person behind the name