Fomepizole

Fomepizole is an alcohol dehydrogenase inhibitor used in management of methanol and ethylene glycol poisoning. It is not currently available in either Australia or New Zealand. 


Administration:

  • Loading dose = 15 mg/kg in 100ml of 0.9% saline or 5% dextrose IV over 30 minutes.
  • Maintenance dose = 10 mg/kg in 100ml of 0.9% saline or 5% dextrose IV over 30 minutes every 12 hours for 48 hours.
  • If given for >48 hours you will need to increase the dose to 15 mg/kg to compensate for induction of metabolism.
  • If the patient undergoes dialysis, fomepizole should be given every 4 hours or as a continuous infusion at 1 mg/kg/hour for the entire duration of the haemodialysis

References

toxicology library antidote 700 1

Toxicology Library

Antidote

Dr Neil Long BMBS FACEM FRCEM FRCPC. Emergency Physician at Burnaby Hospital in Vancouver Emergency. Loves the misery of alpine climbing and working in austere environments. Supporter of FOAMed, toxicology, tropical medicine, sim and ultrasound

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