Frederick Weber

Frederick Parkes Weber (1863-1972) enhanced

Frederick Parkes Weber (1863-1972) was an English physician and dermatologist

His clinical writings span more than 1,200 articles and 23 books, establishing him as one of the most productive medical authors of his era. Weber’s keen diagnostic insight contributed to the characterisation of vascular anomalies and rare dermatological conditions, including Rendu-Osler-Weber disease and Sturge-Weber-Kalischer syndrome.

Educated at Charterhouse School, Trinity College Cambridge, and St. Bartholomew’s Hospital, Weber augmented his training in Vienna and Paris. He served as physician to the German Hospital, Dalston, for nearly five decades and also held posts at Mount Vernon Hospital and Brompton Hospital. His dedication to medicine extended well into his later years, remaining active in clinical practice and the Royal Society of Medicine into his 90s.

Weber was also a scholar of medical philosophy and the arts. His book Aspects of death and correlated aspects of life in art, epigram, and poetry reflected a unique blend of scientific inquiry and humanistic perspective. Beyond medicine, he was an accomplished numismatist, collaborating with his father Sir Hermann Weber (1823-1918) to build a renowned coin collection now housed in major museums worldwide.

His remarkable contributions to medicine and medical literature, combined with his wide-ranging intellectual pursuits, earned him an enduring place among Britain’s most distinguished physicians.

Biography
  • 1863 (May 8) – Born in London; eldest son of Sir Hermann David Weber (1823–1918), personal physician to Queen Victoria, and Matilda Gruning.
  • 1874–1881 – Educated at Temple Grove School, East Sheen; then Charterhouse School.
  • 1882 – Entered Trinity College, Cambridge.
  • 1886 – BA, Cambridge.
  • 1889 – MB BCh, Cambridge.
  • 1890 – MA, Cambridge; MRCP.
  • 1892 – MD, Cambridge; completed doctoral thesis on nephritis and pulmonary tuberculosis.
  • 1890s – House Surgeon and House Physician at St. Bartholomew’s Hospital; House Physician at Brompton Hospital; postgraduate studies in Vienna and Paris.
  • 1894 – Honorary Physician to German Hospital, Dalston; began tenure lasting nearly 50 years.
  • 1894 – Joined Pathological Society of London; frequent contributor to its Transactions and Journal.
  • 1899–1911 – First Assistant Physician, then Physician, at Mount Vernon Hospital for Chest Diseases.
  • 1906 – Disposed of personal coin collection; significant donations made to British Museum, Bodleian Library, Fitzwilliam Museum, and Boston Medical Library.
  • 1921 – Delivered first Mitchell Lecture at Royal College of Physicians: The Relations of Tuberculosis to General Bodily Conditions and to Other Diseases.
  • 1930 – Awarded Moxon Gold Medal by the Royal College of Physicians for distinguished clinical observation and research.
  • 1943 – Festschrift presented on his 80th birthday: seven volumes of reprints and bibliography of nearly 1,000 works.
  • 1962 (June 2) – Died peacefully in his 100th year; survived by his wife Dr Hedwig Unger-Laissle.
Medical Eponyms
Klippel-Trénaunay-Weber syndrome (1900)

Klippel-Trenaunay syndrome (KTS) is a rare congenital cutaneous vascular malformation syndrome. Diagnosis is made with two of the three classic signs of localised cutaneous capillary malformations, venous abnormalities, and limb hypertrophy.

Also known as capillary-lymphatic-venous malformation (CLVM). It is associated with a a wide spectrum of clinical findings that can manifest during infancy and can progress throughout childhood and adulthood.

This syndrome is part of the PIK3CA-related overgrowth spectrum of diseases, which are caused by mutations in the PIK3CA gene.

1900 – Maurice Klippel (1858-1942) and Paul Trénaunay (1875-1938) reported a patient with asymmetrical hypertrophy of the soft tissue and bone, together with haemangiomatous lesions of the skin, using the term “naevus variqueux ostéo-hypertrophique”

1907 – Weber described three more cases and proposed the classic triad of “dermal naevi, osseous and soft tissue hemihypertrophy, and varicose veins.“

1918 – Weber revised the description to “hemangiectatic hypertrophy of limbs, congenital phlebarteriectasis and so-called congenital varicose veins“. He added an additional component, congenital arteriovenous fistula. Thereafter the triple-barreled eponym came into use. 

Peutz-Jeghers syndrome

1896 – Sir Jonathan Hutchinson published the portraits and further description of the twins described by Connor in his article titled ‘Pigmentation of lip and mouth‘. He wrote that these twins “developed a number of black pigmented spots on the lips and inside of the mouth“, which had increased in size and number since appearing at three-years of age

1919 – Weber published an update on the twins, confirming that one of the twins died following a surgical procedure for intussusception at age 20-years. Intestinal polyposis was not specifically confirmed as the cause of intussusception. The second twin died at age 52-years of breast cancer, confirmed by her brother to Harold Joseph Jeghers (1904-1990)

Pfeifer-Weber-Christian disease (PWCD)

Rare idiopathic disease characterised by lobular panniculitis of adipose tissue with systemic symptoms and multiple organ involvement. PWCD is a rare illness of unknown aetiology, with a higher prevalence in females.

It is characterised by recurrent fever associated with the appearance of single or multiple non-suppurative nodules, sometimes tender, ranging from 1-12cm in diameter. The trunk and extremities, particularly the thighs and legs, are most frequently affected. Hands, face, and feet usually spared.

1892 – German physician, Victor Pfeifer (1846-1921) was the first to first describe multiple areas of atrophy in subcutaneous fatty tissue

1925 – Weber presented a case of a woman he treated at the German hospital in 1924 and termed the process relapsing non-suppurative nodular panniculitis.

1928 – The American physician, Henry Asbury Christian (1876-1951) highlighted the relapsing nature of the relapsing fever associated with the nodular nonsuppurative panniculitis

Pfeifer-Weber-Christian disease (PWCD) relapsing fever
Fig 10. Temperature chart during the 5th attack. Christian 1928
deep irregular depressions in the cutaneous surface
Fig 8. Deep irregular depressions in the cutaneous surface of the legs of a patient suffering from an attack of febrile nodular nonsuppurative panniculitis. Christian 1928
Rendu-Osler-Weber disease

Rendu-Osler-Weber disease (aka Hereditary haemorrhagic telangiectasia (HHT)) is an autosomal dominant disorder characterised by epistaxis, cutaneous telangiectasia, and visceral arteriovenous malformations (AVMs).

Characteristic lesions are telangiectases – focal dilatations of postcapillary venules and AVMs. Recurrent epistaxis often restricts daily life and AVMs can cause serious complications if located in the lungs, liver, or brain.

1907 – Weber provided a clinical description in a series of cases; and provided a summary of the world literature to date. He would later expand further with more cases in 1936

Mrs. Sarah S…has a number of bright red angiomata distributed over the face, ears, lips, tongue, mucous membrane of the mouth, and the conjunctival surfaces of the four eyelids. All these angiomata are small; many, including those on the tongue and inside of the mouth, are hardly as large as an ordinary brass pin’s head (punctiform angiomata)

On the mucous membrane inside both nostrils there are some telangiectases…On the fingers, and notably under the finger-nails, there are several minute (pinpoint) red angiomata, which I had not observed until Professor W. Osler, when he recently saw the patient, kindly drew my attention to them.

Weber 1907

Rendu-Osler-Weber disease Weber 1936
FIG. 1.—Hereditary Haemorrhagic Telangiectasia of the Osler type, of late onset. Weber 1936

Sturge-Weber syndrome

Weber-Cockayne syndrome

Major Publications
References

Biography

  • Obituary. British Medical Journal, 1962; 1(5293): 1541–1543.
  • Munk’s Roll. Frederick Parkes Weber. Royal College of Physicians

Eponymous terms

Klippel-Trénaunay-Weber syndrome

Pfeifer-Weber-Christian disease (PWCD)

Rendu-Osler-Weber disease

Eponym

the person behind the name

more eponyms…

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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