Fuchs endothelial corneal dystrophy is characterised by bilateral endothelial cell loss.  Examination signs include:

  • central guttata – the presence of irregular warts or excrescences on Descemet membrane secreted by abnormal endothelial cells
  • tiny dark spots caused by distribution of the regular endothelial mosaic which progress to a ‘beaten metal appearance’ 

History of Fuchs corneal dystrophy

1910Ernst Fuchs (1851-1930) reported 13 cases of central corneal clouding, loss of corneal sensation and formation of epithelial bullae which he labelled as ‘dystrophia epithelialis corneae’

1913 – Exacerbation of the disease post cataract surgery was noted

1920’s – The pathophysiology of Fuchs’ dystrophy was recognised as primarily a disease of the corneal endothelium, with Alfred Vogt a Swiss Ophthalmologist first using the term ‘central guttata’ in 1921

Associated Persons

Alternative names
  • Fuchs’ endothelial-epithelial dystrophy


Did they first describe or popularise or plagiarise?


Historical references

  • List

Eponymous term review


the names behind the name

Associate Professor Curtin Medical School, Curtin University. Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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