Funtabulously Frivolous Friday Five 312

Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF, introducing the Funtabulously Frivolous Friday Five 312 – photo quiz 2 – phFFFF:

Question 1
Name the disease from the sign:

Reveal the funtabulous answer

‘Moon facies’ of Cushing Syndrome.

Moon facies refer specifically to the facial features caused by rapid increase in adiposity of the face, neck and trunk in glucocorticoid excess; either exogenous or endogenous (pituitary tumour). Harvey Williams Cushing (1869 – 1939) published his first descriptions of 12 such cases in 1932, later that year he published two more cases and first used the term ‘round moon face’.

The case description was provided to Cushing in 1930 by Julius Bauer, a professor of Medicine in Vienna. Bauer used the German term vollmondgesicht, meaning “full moon face”. A still earlier use of a moon simile to describe facial pathologic abnormalities dates back to 1873 when Sir William Gull, an English physician, gave one of the first descriptions of myxoedema: 

her face alternating from oval to round, much like the full moon at rising.

Sir William Gull


Question 2
Name the disease:

Reveal the funtabulous answer

Graves Disease

Graves disease is the most common cause of hyperthyroidism, the lifetime risk is 3% for women and 0.5% for men.  The incidence peaks between 30 and 50 years of age, but people of any age can be affected. 

Named after Robert James Graves (1796 – 1853), it is an autoimmune disease characterized by hyperthyroidism precipitated by circulating autoantibodies. Thyroid-stimulating immunoglobulins bind to and activate thyrotropin receptors, causing thyroid hypertrophy and increased synthesis of thyroid hormones. In some patients, Graves disease is part of more extensive autoimmune processes that lead to multiple organ dysfunction (e.g. polyglandular autoimmune syndromes).


Question 3
Name the disease:

Reveal the funtabulous answer

Migraine, meaning ‘half skull’.

Tracing the origin of the term ‘migraine’ takes quite a few steps, from the Oxford dictionary:

“Late Middle English from French, via late Latin from Greek hēmikrania, from hēmi– ‘half’ + kranion ‘skull’.

Question 4
What disease is shown here:

Reveal the funtabulous answer

Cauliflower ear – auricular haematoma. 

Acute auricular hematoma is usually caused by blunt trauma or other injury to the external ear.  It is most common to boxers, rugby players and wrestlers.  The full cauliflower ear deformity comes from scarring fibrocartilaginous deformity. 

From a series of experiments conducted in the mid-1970s when weights were dropped on the ears of rabbits, researchers concluded hematomas in the inter-cartilaginous space were responsible for the deformity. However, further testing (and more rabbits), showed blood accumulation in the subperichondrial space was responsible for disrupting circulation and further necrosis.  The hematoma is then replaced by chondroblasts. This process sets a cascade of fibrosis and contracture, and the subsequent development of cauliflower ear.


Question 5
Bloody good album, bloody awful syndrome.
Beatles album 1

Reveal the funtabulous answer

HELLP syndrome. 

HELLPHaemolysis, Elevated Liver enzymes and Low Platelets.  

This syndrome occurs in one to six per 1000 pregnancies, maternal death has been reported in 1–24% of cases.  Hypertension and proteinuria which characterise pre-eclampsia are more often absent in presentations of HELLP syndrome which is often less specific.  HELLP typically presents in third trimester but can also occur in early puerperium. Symptoms may include fatigue and malaise, fluid retention, headache, nausea and vomiting, RUQ abdominal pain, blurred vision, epistaxis, and seizures. It is most common in women with pre-eclampsia and eclampsia.


…and finally


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Funtabulously Frivolous Friday Five

Dr Mark Corden BSc, MBBS, FRACP. Paediatric Emergency Physician working in Northern Hospital, Melbourne. Loves medical history and trivia...and assumes everyone around him feels the same...| LinkedIn |

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