Helene Ollendorff

Helene Ollendorff Curth (1899 – 1982)

Helene Ollendorff Curth (1899 – 1982) was a German-American dermatologist.

One of the first female pioneers in academic dermatology and the study of genodermatoses. She is also the first (and only) person to be eponymously celebrated with her maiden and married names.

Eponymous terms include Ollendorf probe sign (1923); Buschke-Ollendorff syndrome (1928); Curth-Macklin syndrome (1954); and the Curth criteria for the diagnosis of cutaneous paraneoplastic syndromes (1976)


Biography
  • Born to a Jewish family on 18 February 1899 as Helene Ollendorff in Breslau, Germany
  • Studied medicine at the universities of Freiburg, Munich and Breslau graduating in 1923.
  • 1924 trained in dermatology at the Rudolf-Virchow-Krankenhaus in Berlin under Profesor Abraham Buschke. Here she met her husband Rudolf Wilhelm Paul Curth.
  • 1927 Married Dr. William Curth taking the Curth surname, whilst retaining her own as an unhyphenated forename Helene Ollendorff Curth (H. O. Curth).
  • To escape Nazi Germany the Curths moved to New York in 1931. Here they started their own private practice whilst pursuing academic careers at the University of Columbia.
  • Died in 1982. She suffered from Alzheimer’s disease in her later years and donated her brain to medical research.

Medical Eponyms
Ollendorf probe sign (1923)

Describes the extreme sensitivity of papular lesions of secondary syphyllis to touch. This sign is still used to aid diagnosis today.


Buschke-Ollendorff syndrome (1928)

Also known as Dermatofibrosis lenticularis disseminata with osteopoikilosis

Autosomal dominant connective tissue disorder manifesting as multiple subcutaneous nevi or firm, nontender nodules. These nodules are usually skin to yellow coloured and painless. On histologic examination the lesions may be elastin-rich (elastoma) or collagen-rich (dermatofibrosis lenticularis disseminata). Affected individuals also have osteopoikilosis (OPK) – ‘spotted bones,’ with osteosclerotic foci found in the epiphyses and metaphyses of the long bones, wrist, foot, ankle, pelvis, and scapula. It is caused by a mutation in LEMD3 which is a gene that normally controls the production of proteins that support connective tissue. The syndrome is usually asymptomatic so treatment is mostly not required. Excision of skin nodules can be considered.

Abraham Buschke (1868-1943) and Ollendorff first reported the disease in 41 year old women in 1928. They highlighted the combination of skin and bone findings.

The posthumous eponymous term Buschke-Ollendorff was introduced by Schimpf et al in 1979.


Curth-Macklin syndrome (1954)

In 1954, Madge Thurlow Macklin (1893–1962) and Helene Ollendorff Curth (1899-1982) reported, a form of ichthyosis hystrix, a rare congenital genodermatosis. Ichthyosis hystrix of Curth-Macklin (IHCM) is an autosomal dominant skin disorder characterized by extensive hyperkeratosis and palmo-plantar keratoderma. It is caused by a mutation in KRT1 gene which is involved in keratin production. There is no cure but management includes salt waters bath, moisturising cream and oral retinoids in severe cases. It is also one of the first syndromes to be named after two women.

In 1952, Curth examined on Long Island, New York, two probands suffering from widespread ichthyosis hystrix of a family of English origin. The results of this clinical examination together with a genetic analysis by Macklin were published in 1954

…we are justified in assuming that our cases, clinically as well as histologically and ultrastructurally, represent a special form among the various forms of inherited ichthyoses and thus must be regarded as an independent nosological entity. In designating this type we prefer the term “Ichthyosis hystrix type Curth-Macklin”.

Curth 1972
Ichthyosis hystrix type Curth-Macklin 1970
Keratoses and contractions of palms and feet of III/25.
Curth 1970

Curth’s criteria for the diagnosis of cutaneous paraneoplastic syndromes (1976)

Curth studied acanthosis nigricans in considerable depth. She noted that there was two forms benign and malignant (associated with underlying cancer) and that the benign type was often found to present at a younger age and in those with a genetic disposition.

She proposed criteria to assess the causal relationship between dermatological change and potential underlying malignancy. Requirements included:

  1. both conditions start at the same time,
  2. both conditions follow a parallel course,
  3. the condition is not recognized as part of a genetic syndrome,
  4. a specific tumor occurs with a certain dermatosis,
  5. the dermatosis is not common, and
  6. a high percentage of the association is noted.

Cutaneous paraneoplastic lesions can precede the presentation of malignancy and therefore their recognition may help to achieve early diagnosis. These criteria have therefore been important in cancer diagnosis.


Major Publications

References

Biography

Eponymous terms


eponymictionary CTA

eponym

the person behind the name

Studied at University of Leeds-MBChB and Microbiology in Relation to Medicine BSc. British doctor currently working in Emergency Medicine in Perth, Australia.

Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM with a passion for rugby; medical history; medical education; and informatics. Asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | vocortex |

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