Murphy’s sign is elicited in patients with acute cholecystitis by asking the patient to take in and hold a deep breath while palpating the right subcostal area. If pain occurs on inspiration, when the inflamed gallbladder comes into contact with the examiner’s hand, Murphy’s sign is positive.
Note: Murphy originally described his sign as palpation under the right costal margin with the patient upright in a seated position on deep inspiration. Moynihan’s modified sign requires the patient to be supine akin to modern textbook descriptions of Murphy’s sign
1896 – Bernhard Naunyn (1839 – 1925) in his treatise on cholelithiasis described clinical examination for gallstones with palpation in the right upper quadrant on inspiration and comparing right and left hypochondria.
If the liver is swollen as the result of the attack (i.e., recently) the organ is always more or less tender, and often very acutely so; but frequently it is tender without being swollen. In such cases it is found that pain is induced when, during a deep inspiration, pressure is made with the hand as far upwards as possible beneath the right costal border. At the moment when the liver impinges upon the tips of the fingers the patient experiences a deep-seated pain which sometimes radiates over the entire hepatic region and on to the epigastrium. By no means rarely, however, the tenderness of the liver is only manifested by tension of the muscles of the anterior abdominal wall on the right side, and in such cases the difference in tension of the right and left side respectively is best observed in the rectus abdominis.
1903 – John B. Murphy (1857 – 1916) described his clinical examination sign in patients with acute cholecystitis. Murphy examined the sitting patient from behind with fingers gripped under the right costal margin. Pain elicited at the height of inspiration evokes a positive test.
The most characteristic and constant sign of gall-bladder hypersensitiveness is the inability of the patient to take a full, deep inspiration, when the physician’s fingers are hooked up deep beneath the right costal arch below the hepatic margin. The diaphragm forces the liver down until the sensitive gall-bladder reaches the examining fingers, when the inspiration suddenly ceases as though it had been shut off. I have never found, this sign absent in a calculous or infectious case of gall-bladder, or duct disease.Murphy 1903: 827-828
Murphy’s Percussion Test – Murphy also described a perpendicular percussion technique for evaluation of the inflamed gallbladder
1905 – Berkeley Moynihan (1865 – 1936) acknowledged Murphy’s 1903 description of right upper quadrant interrogation in the upright patient with fingers gripped under the lower right anterior costal margin. He also took into account Naunyn’s 1896 description of right upper quadrant examination on inspiration.
I have found the simplest method of eliciting the pressure signs to be this: While the surgeon sits on the edge of the couch, to the right of the patient, the left hand is laid over the lower part of the right side of the patient’s chest, so that the thumb lies along the rib-margin; as a deep breath is taken the thumb is pressed upwards towards the under surface of the liver.Moynihan 1905
The presence of Murphy’s sign has been shown to be both sensitive (97.2%) and highly predictive (93.3%) of a positive hepatobiliary scintigraphy in patients with suspected acute cholecystitis: Singer AJ. Ann Emerg Med. 1996
Murphy’s Sign should be used with caution in elderly patients. A positive sign is useful, however a negative sign is not reliable to rule out acute cholecystitis and further diagnostic tests should be instigated.
- The diagnostic accuracy for acute cholecystitis was 80% dropping to 34% when the sign was negative.
- The positive predictive value of the test in elderly people was 0.58, with a sensitivity of 0.48 and a specificity of 0.79: Adedeji OA. J R Coll Surg Edinb. 1996
Of note: None of the trials evaluate the sign originally described by Murphy, rather Moynihan’s modification of Murphy’s sign
- Bernhard Naunyn (1839 – 1925)
- John Benjamin Murphy (1857 – 1916)
- Berkeley George Andrew Moynihan (1865 – 1936)
- Murphy Sign
- Moynihan’s sign; Moynihan’s modification
- Naunyn B. A treatise on cholelithiasis. London: The New Sydenham Society 1896
- Murphy JB. The diagnosis of Gall-stones. The Medical News (London). 1903; 82(2): 825-883
- Moynihan B. Gall-stones and their surgical treatment. 1905: 150-151
- Murphy JB. Gallstone disease and its relation to intestinal obstruction. Illinois Medical Journal. 1910; 18: 272-280
- Murphy JB. 5 diagnostic methods of John B, Murphy. The Surgical Clinics of John B. Murphy, 1912; 1(1): 459-466
- Murphy, JB. Cholelithiasis. The Surgical Clinics of John B. Murphy, 1912; 1(1): 417-428
- Singer AJ, McCracken G, Henry MC, Thode HC Jr, Cabahug CJ. Correlation among clinical, laboratory, and hepatobiliary scanning findings in patients with suspected acute cholecystitis. Ann Emerg Med. 1996; 28(3): 267-72
- Adedeji OA, McAdam WA. Murphy’s sign, acute cholecystitis and elderly people. J R Coll Surg Edinb. 1996; 41(2): 88.
- Salati SA, al Khadi A. Murphy’s sign of cholecystitis– a brief revisit. Journal of Symptoms and Signs. 2012; 1(2): 53-56
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