
Dabigatran and Bleeding
Dabigatran is a direct thrombin inhibitor; It is viewed as a warfarin replacement; It's use is controversial because the management of bleeding complications is difficult and there is no definitive antidote

Dabigatran is a direct thrombin inhibitor; It is viewed as a warfarin replacement; It's use is controversial because the management of bleeding complications is difficult and there is no definitive antidote

Respiratory Alkalosis DDx

Respiratory Acidosis DDx

Metabolic acidosis DDx

Urea (Blood Urea Nitrogen – BUN) is the chief end product of protein metabolism. it is formed in the liver from ammonia and excreted by the kidneys. Urea accounts for 50% of serum non-protein nitrogen Causes of Increased serum urea…

Hypomagnesaemia: Defined as serum magnesium < 0.75 mmol/L; associated with increased ICU mortality common — affects 10-65% of ICU patients

Indications: Evaluate the adequacy of ventilation, acid–base status, and oxygenation. Evaluate the patient’s response to therapy and/or diagnostic evaluation (e.g. oxygen delivery). Monitor severity and progression of a known disease process. Contraindications: Modified Allen test gives a negative result, indicating…

Methanol Toxicity

Regional Citrate Anticoagulation is the infusion of citrate into the blood circuit during renal replacement therapy (RRT) to chelate ionized Ca2+ forming calcium-citrate complexes, thus preventing coagulation of blood; calcium is required for the generation of thrombin (involved in the activation of factors II, IX and X)

Neuroleptic Malignant Syndrome: life-threatening extrapyramidal complication of using neuroleptic drugs

Anticholinergic Syndrome

Sympathomimetic toxidrome