Succimer

Succimer (DMSA) is an orally active metal chelator is used to treat heavy metal poisoning. In adults Succimer is used for symptomatic lead poisoning or in patients who are asymptomatic with levels >60 micrograms/dL (>2.9 micro mol/L). In paediatrics it is used for symptomatic lead poisoning or in patients who are asymptomatic with levels >45 micrograms/dL (>2.17 micro mol/L).


Administration:

  • Administer 10 mg/kg orally 3 times/day for 5 days. Then…. 10 mg/kg orally 2 times/day for 14 days.
  • Blood levels are required following completion of the initial course of succimer.
  • In those that are critically unwell the use of sodium calcium edetate is recommended.
  • Adverse reactions include gastrointestinal upset, transient liver function abnormalities in 60% and reversible neutropenia.

References

toxicology library antidote 700 1

Toxicology Library

Antidote

Dr Neil Long BMBS FACEM FRCEM FRCPC. Emergency Physician at Burnaby Hospital in Vancouver. Loves the misery of alpine climbing and working in austere environments. Supporter of FOAMed, toxicology, tropical medicine, sim and ultrasound

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