Tag Clinical trials
CCC Critical Care compendium 340


Randomisation is the process of assigning clinical trial participants to treatment groups such that each participation has a known (usually equal) chance of being assigned to any of the groups
CCC Critical Care compendium 340

Adaptive Trial Designs

An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial
CCC Critical Care compendium 340

Before-and-after studies

Non-experimental observational study design used to assess the effect of an intervention based on comparison of outcomes prior to its use and afterward
CCC Critical Care compendium 340

How to analyse a clinical trial

Clinicians must be able to critically appraise clinical trials to determine their internal validity. Trials should adhere to the CONSORT statement (CONsolidated Standards of Reporting Trials)
CCC Critical Care compendium 340

Power and Sample Size

It is unethical and a waste of time and resources to embark on a study when there is a high chance of a false negative result (Type II error). The commonest cause of this is having a sample size that is too small
Research EBM 340

The Devil is in the Details

In part one of a series on clinical trials, David Denman discusses CONSORT diagrams and the CONSORT statement using the DECRA trial as an example.