Tag Glucagon


Polypeptide hormone secreted by the alpha-cells of the pancreas. Supra-physiological doses have previously been advocated in the management of beta-blocker and calcium channel blocker poisoning but this practice is now largely abandoned.
CCC Critical Care compendium 340

Glucagon as an Antidote

Glucagon is traditionally considered a first line antidote for beta-blocker overdose. Glucagon has also been used in the setting of calcium channel blocker toxicity
CCC Critical Care compendium 340

Glucagon Therapy

Agonist at glucagon-specific Gs-protein coupled receptor, activates adenylyl cyclase resulting in increased [cAMP]i