ACEM Primary Pharmacology of Glucagon: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
Polypeptide hormone secreted by the alpha-cells of the pancreas. Supra-physiological doses have previously been advocated in the management of beta-blocker and calcium channel blocker poisoning but this practice is now largely abandoned.
Glucagon is traditionally considered a first line antidote for beta-blocker overdose. Glucagon has also been used in the setting of calcium channel blocker toxicity
Agonist at glucagon-specific Gs-protein coupled receptor, activates adenylyl cyclase resulting in increased [cAMP]i
the case. a 36 year old male presents to your ED at 2am with retrosternal pain and concern that last nights steak “got stuck and didn’t go down”. He has vomited once and now continues to spit out saliva as…