Pharm 101: Glucagon
ACEM Primary Pharmacology of Glucagon: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
Tag Glucagon
Glucagon
Polypeptide hormone secreted by the alpha-cells of the pancreas. Supra-physiological doses have previously been advocated in the management of beta-blocker and calcium channel blocker poisoning but this practice is now largely abandoned.
Glucagon as an Antidote
Glucagon is traditionally considered a first line antidote for beta-blocker overdose. Glucagon has also been used in the setting of calcium channel blocker toxicity
Glucagon Therapy
Agonist at glucagon-specific Gs-protein coupled receptor, activates adenylyl cyclase resulting in increased [cAMP]i