Valproate: Still Big Trouble!
The patient from Toxicology Conundrum 055 with a massive valproate overdose arrives in the ICU, can you manage things from here?
Tag valproic acid
Valproate: Big Dose, Big Trouble!
A man presents with decreased level of consciousness following a probable ingestion of 96g of sodium valproate. Can you handle this toxicological emergency?
Valproic Acid
Valproic acid (sodium valproate) in overdose results in CNS depression and large overdoses can result in multi-system organ failure and death. Chronic toxicity can cause life threatening hyperammonia and hepatotoxicity.
Sodium Valproate Overdose
Sodium valproate is a commonly used anti-epileptic drug, that come sin standard and enteric coated forms. Toxicity is characterised by metabolic failure, resulting in multi-organ dysfunction and cerebral edema
Sodium Valproate
Sodium Valproate: anticonvulsant; decreasing neuronal excitability or enhancing inhibition of neuronal transmission.