Month January 2019
CCC Critical Care compendium 340

Co-trimoxazole

Co-trimoxazole: 2 antibiotics (sulfamethoxazole and trimethoprim) -> blocks two consecutive steps in the biosythesis of nucleic acids and proteins essential to bacteria.

CCC Critical Care compendium 340

Carotid Endarterectomy

Carotid Endarterectomy = removal of atheromatous plaque from the ICA. Artery clamped, open, plaque stripped and then closed directly or with a Gore-Tex vein patch.

CCC Critical Care compendium 340

AAA Repair Patient Hot Case

GENERAL APPROACH Emergency or Elective End-organ damage Complications– brain injury– spinal cord ischaemia– ileus– MI– lower limb ischaemia– compartment syndromes– renal injury INTRODUCTION CUBICLE dialysis INFUSIONS vasoactives fluid boluses sedation analgesia transpyloric feeding: ileus, ischaemia TPN VENTILATOR mode level of…

CCC Critical Care compendium 340

Clopidogrel

Clopidogrel: anti-platelet agent; inhibition of the ADP platelet receptor and subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex -> inhibits platelet aggregation

CCC Critical Care compendium 340

COX II Inhibitors

Selective COX-2 inhibitors developed to try and inhibit prostacyclin synthesis by the COX-2 isoenzyme induced at sites of inflammation without affecting the action of the constitutively active COX-1 isoenzyme found in gastic mucosa, platelets & kidney.

CCC Critical Care compendium 1200

Dipyridamole

Dipyridamole: anti-platelet + vasodilator. Potentiates the effect of prostacyclin or by inhibiting phosphodiesterase enzyme activity -> increase intracellular cAMP; inhibits cellular uptake of adenosine -> more available to act on coronary vessels -> vasodilation

CCC Critical Care compendium 340

Post Operative Confusion

OVERVIEW RISK FACTORS CAUSES Anaesthetic Surgical INVESTIGATIONS MANAGEMENT Resuscitate Electrolytes and Acid-base Specific Therapy Underlying Cause References and Links

CCC Critical Care compendium 340

PRES

Posterior reversible encephalopathy syndrome (PRES) is a syndrome of 'cephalgia, convulsions, confusion, and vision loss' (CCCV) typically in the context of severe hypertension

CCC Critical Care compendium 340

Dobutamine

Dobutamine: synthetic isoprenaline derivative; adrenergic agonist; racemic mixture: -> inotropy with some vasodilation

CCC Critical Care compendium 340

Dopamine

Dopamine: naturally occurring catecholamine; dopamine and adrenoreceptor agonist; immediate precursor to noradrenaline