Burns Literature Summaries
Herndon DN et al. A comparison of conservative versus early excision. Therapies in severely burned patients. Ann Surg. 1989 May;209(5):547-52; discussion 552-3. [PMC1494069]
- RCT
- single centre
- n = 85
- inclusion criteria: > 30% TBSA burn
- early excision VS topical antimicrobials + skin grafting after spontaneous eschar separation
-> mortality from burns without inhalational injury decreased by early excision
-> reduces hypermetabolic response to burns
-> reduces infection
-> improves cosmesis
Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001 Oct 25;345(17):1223-9. [PMID 11680441]
- RCT
- n = 25
- inclusion: children, > 40% TBSA
- propanolol PO vs placebo
-> significant reduction in heart rate, resting energy expenditure
-> increased muscle-protein balance
Navar PD, Saffle JR, Warden GD. Effect of inhalation injury on fluid resuscitation requirements after thermal injury. Am J Surg. 1985 Dec;150(6):716-20. [PMID 4073365]
- n = 171
- inclusion: thermal burns covering >25% TBSA
- Parkland formulae resuscitation + additional fluids targeting a urine output 30-50mL/hr
- 51 patients had an inhalational injury
-> these patients required 50% more fluid
Critical Care
Compendium
Chris is an Intensivist and ECMO specialist at The Alfred ICU, where he is Deputy Director (Education). He is a Clinical Adjunct Associate Professor at Monash University, the Lead for the Clinician Educator Incubator programme, and a CICM First Part Examiner.
He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. He was one of the founders of the FOAM movement (Free Open-Access Medical education) has been recognised for his contributions to education with awards from ANZICS, ANZAHPE, and ACEM.
His one great achievement is being the father of three amazing children.
On Bluesky, he is @precordialthump.bsky.social and on the site that Elon has screwed up, he is @precordialthump.
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