Category Investigations
CCC Critical Care compendium 340

Platelet Function Assays

PFA-100 = citrated whole blood placed in a disposable cartridge containing a membrane coated with collagen/adrenaline or collagen/ADP into which a microscopic aperture has been cut -> with high shear rates contact of blood with the membrane causes platelets to aggregate and occlude the aperture.
CCC Critical Care compendium 340

Thromboelastogram (TEG)

Thromboelastography (TEG) is a viscoelastic hemostatic assay that measures the global viscoelastic properties of whole blood clot formation under low shear stress
CCC Critical Care compendium 340

VBG versus ABG

Reviewed and revised 7 January 2016 OVERVIEW Venous blood gases (VBG) are widely used in the emergency setting in preference to arterial blood gases (ABG) as a result of research published since 2001 The weight of data suggests that venous pH…

CCC Critical Care compendium 340

Creatinine

Creatinine = Non-protein end product of creatinine metabolism. Formed from skeletal muscle and excreted in constant amounts. Completely filtered by kidney (marker of GFR). Production proportional to muscle mass
CCC Critical Care compendium 340

Urine Electrolytes

Urinary anion gap (UAG): Differentiate renal or GIT cause of HYPERchloraemic metabolic disorders; or Normal anion gap metabolic acidosis (NAGMA)
CCC Critical Care compendium 340

Urine Transparency

Freshly voided urine is clear and transparent. Cloudy urine may be caused by crystals, deposits, white cells, red cells, epithelial cells or fat globules. Further evaluation with centrifugation, microscopic examination, heating or with ether generally determines the cause of the turbidity.
CCC Critical Care compendium 340

Diabetes Insipidus DDx

Nature: Excessive loss of hypotonic urine Treatment: Fluid resuscitation greater than urine output Cause Central (Failed ADH secretion) Idiopathic (30%) CNS (60%) Tumour 25% Pituitary surgery, Sheehan’s, panhypopituitarism (20%) Head trauma (15%) CNS infection CVA, Aneurysm Sickle cell anaemia Respiratory…

CCC Critical Care compendium 340

Hypercalcaemia DDx

Hypercalcaemia: Nature: Bones, stones, groans and psychic moans. Usually associated with increased calcium release form bones and impaired renal removal and malignancy