The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
GENERAL APPROACH Cause Treatment (source control) — complete or ongoing? Nutrition — NBM? route? nutritional status? Complications – ACS, fungal sepsis? How to move forward? Important causes intra-abdominal sepsis pancreatitis abdominal trauma perforation (e.g. ulcer, appendicitis, diverticulitis, tumor, obstruction, anastomotic…
Acute Graft Versus Host Disease: major complication of allogeneic haematopoietic stem cell transplantation
Hepatic veno-occlusive disease aka sinusoidal obstruction syndrome (SOS) important complication of stem cell transplantation (SCT) mortality >30%
Erythropoietin (EPO) is an endogenous hormone that stimulates erythrocytosis. Role in critical illness is unclear and is limited by the complications of hematopoietic activation (e.g. VTE)
Procedures and Coagulopathy: many procedures are contra-indicated in the presence of coagulopathy; the degree of acceptable coagulopathy for different procedures is controversial
Haemophagocytic lymphohistiocytosis (HLH) may be inherited (AR; 5 subtypes, aka familial HLH) or acquired; may mimic severe sepsis, consider in apparent sepsis without source
COPD Patient Hot Case
Cardiac Arrest Survivor Hot Case
Burns Patient Hot Case
Cryoprecipitate is prepared by thawing fresh frozen plasma (FFP) between 1°C and 6°C and recovering the precipitate
The cold-insoluble precipitate is refrozen.
Reviewed and revised 10 March 2014 OVERVIEW Massive transfusion is defined as A Massive Transfusion Protocol should be used in critically bleeding patients anticipated to require massive transfusion GOALS IN MANAGEMENT OF MASSIVE TRANSFUSION THERAPY INDICATIONS IN MASSIVE TRANSFUSION MASSIVE TRANSFUSION…
Molecular Adsorbent Recirculating System = MARS; short-term extracorporeal hepatic support; so-called ‘liver dialysis’