Acute Cholangitis
Acute or ascending cholangitis is a potentially life-threatening systemic infection resulting from inflammation and infection of the biliary tree due to bacterial growth in the bile, usually in the context of biliary obstruction
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Aerobic Gram Negative Bacteria
COCCI Neisseria meningitides: vaccination, penicillin G or ceftriaxone, rifampicin (prophylaxis) gonorrhoea: piperacillin-tazobactam 4.5g Q8hrly, ceftriaxone Moraxella azithromycin clarithromycin amoxicillin + clavulanate second or third generation cephalosporin co-trimoxazole 10mg/kg of sulphamethoxazole RODS/BACILLI -> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin)…
Antibacterial Resistance
Antibacterial Resistance: Natural Resistance – they do not possess the molecular target of the drug or are impermeable to it; Acquired resistance – occurs through mutation or the acquisition of new genetic material carried by mobile elements
Antimicrobial Quick Reference
Antimicrobial Quick Reference
Antimicrobial Stewardship
Antimicrobial Stewardship is defined as ‘an ongoing effort by a health-care institution to optimise antimicrobial use among hospital patients in order to improve patient outcomes, ensure cost-effective therapy and reduce adverse sequelae of antimicrobial use (including antimicrobial resistance)’
Aspergillosis
Aspergillosis: fungal disease caused by the mold Aspergillus, ranging from hypersensitivity to invasive infection. Important species include Aspergillus fumigatus, niger, flavus, calavtus; transmission by inhalation; high mortality
Bacterial Meningitis
Bacterial meningitis = pyogenic infection of the cerebral ventricles and subarachnoid space -> CSF; usually confined to meninges (although in neonates and adults with Listeria monocytogenes -> cerebritis, encephalitis and abscesses can form)
Candidiasis
Diagnosis and treatment of candidiasis is a contentious issue; invasive candidiasis is difficult to diagnose; >150 species of Candida (a yeast), few are pathogens
Cellulitis
Cellulitis is an uncomplicated non-necrotizing acute infection of the skin involving the hypodermis (mid-to-lower dermis and subcutaneous tissue) and spares deeper structures such as fascia and muscle.
Cholera
Cholera: Gastrointestinal infection caused by vibrio cholerae (Gram negative rod); transmission through consumption of contaminated drinking water or food
Classification of Antibacterial Agents
Classification of Antibacterial Agents