
Acute Graft Versus Host Disease
Acute Graft Versus Host Disease: major complication of allogeneic haematopoietic stem cell transplantation
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.

Acute Graft Versus Host Disease: major complication of allogeneic haematopoietic stem cell transplantation

Hepatic veno-occlusive disease aka sinusoidal obstruction syndrome (SOS) important complication of stem cell transplantation (SCT) mortality >30%

Erythropoietin (EPO) is an endogenous hormone that stimulates erythrocytosis. Role in critical illness is unclear and is limited by the complications of hematopoietic activation (e.g. VTE)

Procedures and Coagulopathy: many procedures are contra-indicated in the presence of coagulopathy; the degree of acceptable coagulopathy for different procedures is controversial

Haemophagocytic lymphohistiocytosis (HLH) may be inherited (AR; 5 subtypes, aka familial HLH) or acquired; may mimic severe sepsis, consider in apparent sepsis without source

COPD Patient Hot Case

Cardiac Arrest Survivor Hot Case

Burns Patient Hot Case

Cryoprecipitate is prepared by thawing fresh frozen plasma (FFP) between 1°C and 6°C and recovering the precipitate
The cold-insoluble precipitate is refrozen.

Reviewed and revised 10 March 2014 OVERVIEW Massive transfusion is defined as A Massive Transfusion Protocol should be used in critically bleeding patients anticipated to require massive transfusion GOALS IN MANAGEMENT OF MASSIVE TRANSFUSION THERAPY INDICATIONS IN MASSIVE TRANSFUSION MASSIVE TRANSFUSION…

Molecular Adsorbent Recirculating System = MARS; short-term extracorporeal hepatic support; so-called ‘liver dialysis’

Acute or ascending cholangitis is a potentially life-threatening systemic infection resulting from inflammation and infection of the biliary tree due to bacterial growth in the bile, usually in the context of biliary obstruction