Antimicrobial Dosing and Kill Characteristics
Dosing is different to non-critically ill patients
Different antimicrobials have different kill characteristics, which can be demonstrated on a concentration vs time graph for antibiotic activity
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Dosing is different to non-critically ill patients
Different antimicrobials have different kill characteristics, which can be demonstrated on a concentration vs time graph for antibiotic activity
See RCH Melbourne Guidelines: Acute Asthma Asthma discharge pack Asthma devices photoboard Using a puffer and spacer to treat acute asthma
Reviewed and revised 8 December 2014 OVERVIEW Cognitive Dispositions to Respond (CDRs) or cognitive biases are: “Predictable tendencies, or biases, to react to contextual clues that are largely unconscious and may contribute to flaws in reasoning; a mental state that embraces…
ILCOR = International Liaison committee on Resuscitation = conglomerate of resuscitation councils worldwide. Changes in 2010
Fluid bolus therapy is widely administered to patients with undifferentiated hypotension and for patients with severe sepsis
The fluid challenge (FC) aims at identifying patients in whom fluid administration improves haemodynamics (known as "fluid responsiveness")
An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial
Blinding and allocation concealment are used in Randomised control trials (RCTs) to reduce systematic bias
Chi-square Test is used to compare categorical data; often displayed in contingency table with rows (x) and columns (y)
Obesity has multiple pathophysiological effects and leads to numerous multi-system complications
Bariatric Patient Hot Case
Reviewed and revised 24 May 2014 OVERVIEW MECHANISM OF ACTION TOXICOKINETICS RISK ASSESSMENT CLINICAL FEATURES Effects include: Complications INVESTIGATIONS (Guided by clinical assessment) Laboratory tests MANAGEMENT Resuscitation Supportive care and monitoring Decontamination Disposition References and Links Journal articles