Category CCC

The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.

CCC Critical Care compendium 1200

Dipyridamole

Dipyridamole: anti-platelet + vasodilator. Potentiates the effect of prostacyclin or by inhibiting phosphodiesterase enzyme activity -> increase intracellular cAMP; inhibits cellular uptake of adenosine -> more available to act on coronary vessels -> vasodilation

CCC Critical Care compendium 340

Post Operative Confusion

OVERVIEW RISK FACTORS CAUSES Anaesthetic Surgical INVESTIGATIONS MANAGEMENT Resuscitate Electrolytes and Acid-base Specific Therapy Underlying Cause References and Links

CCC Critical Care compendium 340

PRES

Posterior reversible encephalopathy syndrome (PRES) is a syndrome of 'cephalgia, convulsions, confusion, and vision loss' (CCCV) typically in the context of severe hypertension

CCC Critical Care compendium 340

Dobutamine

Dobutamine: synthetic isoprenaline derivative; adrenergic agonist; racemic mixture: -> inotropy with some vasodilation

CCC Critical Care compendium 340

Dopamine

Dopamine: naturally occurring catecholamine; dopamine and adrenoreceptor agonist; immediate precursor to noradrenaline

CCC Critical Care compendium 340

Flumazenil

Flumazenil: benzodiazepine antagonist; competitive antagonist that act on the benzodiazepine receptor

CCC Critical Care compendium 340

GI Drug Absorption in Critical Illness

GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)

CCC Critical Care compendium 340

Gentamicin

Gentamicin; aminoglycoside; irreversible binding to bacterial ribosomal proteins -> inhibits protein synthesis; Antimicrobial cover: gram negative rods (including Pseudomonas)