Pandemic Sepsis and Inequality
Flavia Machado discusses Pandemic Sepsis and Inequality. Coda Cure: Conversation 4
Category sepsis
Covid19 and Sepsis Syndromes
Simon Finfer answers the question "Are the Covid19 and Sepsis Syndromes one and the same?" Coda Cure: Conversation 3
Antimicrobial Resistance in COVID-19
The Resistance - Antimicrobial Resistance through a Covid19 lens with Elizabeth Hermsen. Coda Cure: Conversation 2
Pandemic Sepsis Research
Pandemic Sepsis Research through a Covid-19 lens - Are we failing? with Derek C. Angus. Coda Cure: Conversation 1
Initial Management of Sepsis
Reviewed and revised 17 September 2019 OVERVIEW Initial management of sepsis and septic shock involves consideration of: resuscitation early administration of appropriate antibiotics following blood cultures early source control judicious fluid resuscitation, avoiding excess fluids noradrenaline for refractory hypotension (septic shock) inotropes…
Sepsis Overview
The LITFL Critical Care Compendium (CCC) has numerous entries on sepsis, this page collates them
Neutropaenic Sepsis
Febrile neutropaenia (or neutropaenic fever) is defined as: a single temperature measurement >=38.5C, or a sustained temperature >=38C for more than 1 hour; in a patient with a decreased absolute neutrophil count (ANC) of either <0.5 x 109/L, or <1 x 109/L with a predicted nadir of <0.5 x 109/L over the subsequent 48h
The Septic Child
The Septic Child
Procalcitonin
Procalcitonin is the propeptide of calcitonin, a 116-peptide molecule with a molecular weight of 13 kDa. Procalcitonin has been studied as a sepsis biomarker, to help with diagnosing/ ruling out sepsis and to guide the initiation and cessation of antibiotics
Septic encephalopathy
Septic encephalopathy is brain dysfunction mediated by the septic inflammatory response, independent of other co-existent causes such as liver or renal dysfunction
FEAST and Paediatric Fluid Resuscitation
FEAST = Fluid Expansion As Supportive Therapy. Trial was a landmark study investigating the effects of fluid boluses in the resuscitation of febrile children with evidence of poor perfusion
Steroids and Septic Shock Literature Summaries
Bone R.C. et al (1987) “A controlled clinical trial of high dose methylprednisolone in the treatment of severe sepsis and septic shock” NEJM, 317:653-658 PMID 3306374 RCT n = 382 with sepsis and organ dysfunction methylprednisolone (30mg/kg) vs placebo-> no…