
Blood Conservation Strategies
Anemia and blood transfusion is common in the critically ill, and are associated with costs and morbidity/ mortality

Anemia and blood transfusion is common in the critically ill, and are associated with costs and morbidity/ mortality

Tumour Lysis Syndrome: oncological emergency due to turnover of high cell mass malignancies resulting in severe metabolic derangement

von Willebrand Disease: commonest inherited coagulation disorder (autosomal dominant); protein involved in (1) platelet adhesion and (2) carriage of factor VIII; leads to: factor VIII deficiency, abnormal platelet adhesiveness and abnormal vascular endothelium

Venous thromboembolism (VTE) may contribute to up to 12% of deaths in ICU and is the No.1 preventable cause of hospital death; asymptomatic events range from 10-80% in various medical and surgical groups

OVERVIEW Porphyria = group of disorders where patients have a inability to synthesis Hb resulting in an accumulation of precursors oxidised to porphyrins hepatic and erythropoietic varieties 3 hepatic forms that effect are affected by anaesthesia (1) AIP – acute…

Massive venous thrombosis of deep and collateral venous system. Obstruction to outflow causes congestion that can compromise arterial flow

Pancytopaenia

An approach to the patient with persistent bleeding from a venepuncture site

OVERVIEW Lupus Anticoagulants -> result in acquired hypercoagulability due to poorly understood actions ? alteration of the regulation of haemostasis and endothelial cell injury ASSOCIATIONS MANAGEMENT (1) APTT (2) dilute Russell viper venom time (3) silica clotting time(4) kaolin clotting…

Isolated Elevated APTT

Thyroid Storm: life threatening exacerbation of hyperthyroid state with 1 or more organ dysfunction

Myxoedema Coma: extreme form of hypothyroidism; high mortality