Desferrioxamine is an effective iron chelator that is used to treat systemic iron toxicity or prevent the development of systemic toxicity following acute iron overdose. It should ideally be given before iron moves intracellularly and systemic toxicity develops.
- Systemic iron toxicity: Severe gastroenteritis, shock, metabolic acidosis and altered GCS
- Iron levels >90 micro mol/L or 500 microgram/dL at 4-6 hours post ingestion
- Chronic iron overload
- Cardiac monitoring is required.
- Reconstitute 500mg of powder with 5ml of sterile water and dilute in 100ml of 0.9% saline or 5% dextrose.
- Commence IV infusion at an initial dose of 15 mg/kg/hour. Can be reduced if hypotension develops.
- The rate may be increased in life-threatening toxicity up to 40 mg/kg/hour if blood pressure allows.
- Continue the infusion until the patient is clinically stable and the serum iron <60 micro mol/L (350 microgram/dL), but avoid infusion >24 hours (6 hours is usually sufficient).
- Paediatric Dose = same as for adults
- ARDS (for infusions >24 hours)
- Toxic Retinopathy
- Infection (Yersinia and mucormycosis grow avidly with the ferrioxamine complex)
- Rose urine – classical sign but does not necessarily indicate effective chelation.
- Howland MA. Risks of parenteral deferoxamine for acute iron poisoning. Journal of Toxicology – Clinical Toxicology 1996; 34(5):491-497.
- Tenenbein M. Benefits of parenteral deferoxamine for acute iron poisoning. Journal of Toxicology – Clinical Toxicology 1996; 42(5):485-489.
- Tox Library – Iron toxicity