Fred Lange-Nielsen

Biography

• Born on September 28, 1919
• Physician in internal medicine in Tønsberg, Norway
• 1964 – Vice President of International Defence and Aid Fund (IDAF) for Southern Africa
• Died on December 28, 1989

Medical Eponyms

Jervell and Lange-Nielsen syndrome (JLNS) (1957)

Congenital (autosomal recessive) long QT syndrome (LQTS) associated with severe, bilateral sensorineural hearing loss.Two genetic mutations identified encoding cardiac potassium channels. Due to high risk of sudden cardiac death ICD implantation is usually required

1957 – Lange-Nielsen along with Norwegian Professor of Cardiology, Anton Jervell (1901-1987) described an autosomal recessive syndrome of long-QT interval with deafness and sudden death

Four cases of deaf-mutism combined with a peculiar heart disease have been observed in one family. The parents and 2 other children were healthy and had normal hearing. The deaf-mute children all suffered attacks of fainting, probably Adams-Stokes seizures caused by standstill of the heart. The first attack occurred between the ages of 3 and 5 years, and 3 of the children died in such attacks at the ages of 4, 5, and 9 years, respectively.

Electrocardiographic studies in 3 of the cases revealed a marked prolongation of the Q-T interval.

Am Heart J. 1957

Jervell and Lange-Nielson recounted one case of a young boy, born in 1944 suffering from repeated ‘fainting attacks’ since the age of 3. The attacks usually occurred following effort. Occasionally the boy had complained of palpitations and precordial pains. In July, 1953, he was examined with the only pathologic finding being a prolongation of the Q-T interval in the electrocardiogram, worse following exercise. On Nov. 19, 1953, he had a further attack. He suddenly became pale and fell unconscious and died.

Key Attributions

Fred Lange-Nielsen was a bass player and vocalist with:

• String Swing (1937-1941);
• Robert Normann (1942-1954);
• Quartet Hot Dogs;
• Swingsters (with Cecil Aagaard);
• Oslo Swing Club Orchestra;
• Seven Mintre and the Quintet Sy-We-La (1950- 53)

Major Publications

• Jervell A, Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J. 1957 Jul;54(1):59-68.
• Lange-Nielsen F, Retterstol N. Group psychotherapy in bronchial asthma. Acta Psychiatr Scand Suppl. 1959;34(136):187-204.

References

Biography

• Stendahl B, Bergh J. Sigarett Stomp – Jazz i Norge 1940-50. JazzArkivet.no
• Letter From Dr. Fred Lange-Nielsen to MLK. 10 December 1964. TheKingCenter.org
• Bibliography. Lange-Nielson, Fred. WorldCat Identities

Eponymous terms

• Levine SA, Woodworth CR. Congenital deaf-mutism, prolonged QT interval, syncopal attacks and sudden death. N Engl J Med. 1958 Aug 28;259(9):412-7.
• The International Defence and Aid Fund (IDAF). South African History Online. 14 February 2013
• Eponymythology. History of the Electrocardiogram. LITFL

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