Glucagon as an Antidote
Glucagon is traditionally considered a first line antidote for beta-blocker overdose. Glucagon has also been used in the setting of calcium channel blocker toxicity
Digibind
Digibind: trade name for digoxin antidote containing Digoxin-specific antibody Fab fragments; prudent to administer based on a considered risk assessment and before the life-threatening manifestations of digoxin toxicity develop
Digoxin Toxicity
Digoxin toxicity is characterised by gastrointestinal distress, hyperkalemia and life-threatening dysryhthmias, including increased automaticity and AV nodal blockade
Activated Charcoal
Activated Charcoal: decontamination agent; absorbing molecules of drug on its surface -> inhibiting their absorption by as much as 50% -> excretion in faeces
Renal replacement therapy: Dose
Optimal dose of renal replacement therapy (RRT) is controversial... the definition of dose in clinical practice is also a little controversial!
Renal Literature Summaries
Renal Literature Summaries
Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) Circuits: used in renal replacement therapy; therapeutic plasma exchange; and haemoperfusion
Sepsis Literature Summaries
Sepsis Literature Summaries
Opioid Withdrawal
Opioid Withdrawal
Opioid Overdose
Opioid Overdose: miosis; CNS depression; respiratory depression; complications of hypoxia: seizures, dysrrhythmia, brain injury
Paraquat Poisoning
Paraquat Poisoning; highly toxic herbicide; common agent in suicide in 3rd world; leading single agent causing death from pesticide poisoning in many countries including Sri Lanka
Sedative Toxidrome
Sedative toxidrome: agents - opioids; benzodiazepines; barbiturates; baclofen (may mimic brain death, suspect in MS patients); clonidine (mimics opioid toxidrome with marked bradycardia and hypotension)
GHB