CCC Critical Care compendium 340
Meropenem

Meropenem: carbapenem; inhibits cell wall synthesis; empiric treatment for severe sepsis

CCC Critical Care compendium 340
Midazolam

Midazolam: imidazobenzodiazepine; act via benodiazepine receptor in CNS; linked and facilitate action of the GABA receptor; chloride channel activation -> hyperpolarises membrane.

CCC Critical Care compendium 340
Milrinone

Milrinone: bipyridine; non receptor mediated inhibitor of cAMP phosphodiesterase III isoenzyme -> decrease the hydrolysis of cAMP; increase cAMP (analogous to activating a Gs protein)

CCC Critical Care compendium 340
Morphine

Morphine: opioid analgesic; mu and kappa receptor agonist; increase intracellular Ca2+ -> increased K+ conductance -> hyperpolarisation of excitable cell membranes -> decrease in pre & post synaptic responses; reversed by naloxone

CCC Critical Care compendium 340
N-acetylcysteine

N-acetylcysteine (NAC): glutathione supplementation ? protects the liver by maintaining and restoring glutathione levels or by acting as an alternate substrate for conjugation with -> detoxification of reactive metabolites.

CCC Critical Care compendium 340
Naloxone

Naloxone: opioid receptor antagonist; competitive antagonism at mu, kappa and delta receptors -> prevention of binding to endogenous and exogenous opiate receptors.

CCC Critical Care compendium 340
Noradrenaline

Noradrenaline (norepinephrine) hypotension refractory to fluid resuscitation (primarily distributive shock such as septic shock, neurogenic shock, post-bypass vasoplegia and drug-induced)

CCC Critical Care compendium 340
NSAIDs

NSAIDS: Nonsteroidal anti-inflammatory drugs; non-selective COX inhibitors

CCC Critical Care compendium 340
Octreotide

Octreotide: somatostatin analogue; reduces portal hypertension; antidote to sulfonylureas; reduces GI secretions