CCC Critical Care compendium 340
Celecoxib

Celecoxib: COX II inhibitor; blocks access of arachidonic acid to active site at apex of a hydrophobic channel on COX-2

CCC Critical Care compendium 340
Botulism

Botulism: endotoxins from Clostridium botulinum (and other Clostridia) -> prevents the release of Ach -> neuroparalytic disorder; spore forming anaerobes with heat resistant spores found in soil and marine sediment

CCC Critical Care compendium 340
Brain Herniation

Brain herniation is the displacement of part of the brain through an opening or across a separating structure into a region that it does not normally occupy.

CCC Critical Care compendium 340
The Brainstem Rules of Four

OVERVIEW THE FOUR RULES In the rule of 4 there are 4 rules MEDIAL STRUCTURES The 4 medial structures and the associated deficits are: SIDE (i.e. LATERAL) STRUCTURES The 4 ‘side’ (lateral) structures and the associated deficits are: CRANIAL NERVES The 4 cranial nerves in…

CCC Critical Care compendium 340
Ranitidine

Ranitidine: H2 receptor antagonist; competitive blockade of H2 receptors -> decrease in secretion; also decreases action of gastrin and acetylcholine