Alteplase (rtPA)
Alteplase is a tissue plasminogen activator used as a thrombolytic medication in: Acute Ischaemic Strokes, Acute Myocardial Infarction and PE
Amiodarone
Amiodarone: class III anti-arrhythmic; prolongs cardiac action potential & delaying refractory period
Aprotinin
Aprotinin: antifibrinolytic; single chain polypeptide which occurs naturally in bovine lung and other tissues; inhibits fibrionlysis via inactivation of free plasmin
Aspirin
Aspirin: antiplatelet agent; irreversible acetylation of cyclooxygenase -> blocks the production of prostaglandins from membrane phospholipids -> inactivation of platelet aggregation by arachidonic acid and collagen.
Benzylpenicillin
Benzylpenicillin: penicillin antibiotic; inhibition of cell wall synthesis
Bosentan
Bosentan: dual endothelin receptor antagonist; competitive antagonism of endothelin-1 (pulmonary vasoconstrictor) at the endothelin receptors -> decreases PVR
Ceftriaxone
Ceftriaxone: 3rd generation cephalosporin; inhibition of cell wall synthesis: gram –ve rods (except Pseudomonas); gram +ve cocci (except Methicillin resistant and group D streptococci)
Spironolactone
Spironolactone: Potassium sparing diuretic; aldosterone blockade
Classification of Vasoactive Drugs
Classification of Vasoactive Drugs
Oculocephalic and oculovestibular reflexes
Oculocephalic and oculovestibular reflexes are primarily used to determine whether a patient's brainstem is intact (e.g. coma or brain death assessment)
Guillain-Barré Syndrome (GBS)
Guillain-Barré Syndrome (GBS) is the most common and most severe acute paralytic neuropathy, consisting of multiple variants with distinct clinical and pathological features
Hearing Loss in ICU
Hearing Loss in ICU is an under-appreciated problem: Conductive (external ear; middle and inner ear; Sensorineural)