Celecoxib
Celecoxib: COX II inhibitor; blocks access of arachidonic acid to active site at apex of a hydrophobic channel on COX-2
Botulism
Botulism: endotoxins from Clostridium botulinum (and other Clostridia) -> prevents the release of Ach -> neuroparalytic disorder; spore forming anaerobes with heat resistant spores found in soil and marine sediment
Brain Herniation
Brain herniation is the displacement of part of the brain through an opening or across a separating structure into a region that it does not normally occupy.
The Brainstem Rules of Four
'The Brainstem Rules of Four' is an approach to the anatomic localization of brainstem lesions developed by Dr Peter Gates
Bulbar Dysfunction in ICU
Bulbar Dysfunction in ICU
Cerebral oedema
TYPES Cytotoxic edema Vasogenic edema CT FEATURES OF RAISED ICP References and Links
Delayed Awakening in ICU
Delayed Awakening in ICU
Examination of the unconscious patient
Coma is a state of unconsciousness caused by temporary or permanent impairment of the ascending reticular system in the brainstem, or both cerebral hemispheres.
Eye Movements in Coma
A simplified approach to spontaneous eye movements in coma
GBS vs CIP
OVERVIEW References and Links
Ranitidine
Ranitidine: H2 receptor antagonist; competitive blockade of H2 receptors -> decrease in secretion; also decreases action of gastrin and acetylcholine
Magnesium
Magnesium: electrolyte (second most abundant cation in intracellular fluid, after potassium); depresses neuronal activation; essential cofactor in >300 enzyme systems