Pharm 101: Flucloxacillin

Class

Beta-lactam antibiotic

Pharmacodynamics
  • Beta-lactam antibiotic
  • Inhibits bacterial growth by binding to active site of penicillin binding proteins (PBP), interfering with transpeptidation of bacterial cell wall synthesis
  • This leads to cell death (bactericidal)
  • Flucloxacillin is an anti-staphylococcal penicillin, resistant to staphylococcal beta-lactamase
Pharmacokinetics
  • Part biliary excretion, therefore no dose adjustment required in renal failure
  • Given before meals as is food interferes with absorption
  • For other pharmacokinetic properties of penicillins, see Pharm 101: Penicillin G
Antimicrobial activity
  • Resistant to staphylococcal beta-lactamases
  • Active against Staph and Strep
  • Not active against enterococci, gram negative cocci and rods, and anaerobic bacteria
Adverse effects
  • Specific to anti-staphylococcal penicillins (rare):
    • Hepatitis
    • Interstitial nephritis
    • Neutropenia
Further reading
References
Pharm 101 700

Pharmacology 101

Top 200 drugs

MBBS CCPU (RCE, Biliary, DVT, E-FAST, AAA) Rob is an Emergency Medicine Advanced Trainee based in Melbourne, Australia. He has special interests in medical education, ECG interpretation, and the use of diagnostic and procedural ultrasound in the undifferentiated and unwell patient.

Follow him on twitter: @rob_buttner | ECG Library |

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