Funtabulously Frivolous Friday Five 317 - Just when you thought your brain could unwind the medical trivia FFFF
ACEM Primary Pharmacology of Aspirin: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
Salicylate poisoning: mechanisms of toxicity: acid-base disturbance, uncoupling of oxidative phosphorylation, disordered glucose metabolism
Aspirin: antiplatelet agent; irreversible acetylation of cyclooxygenase -> blocks the production of prostaglandins from membrane phospholipids -> inactivation of platelet aggregation by arachidonic acid and collagen.
A 7 year-old girl was brought to hospital with lethargy, irritability and vomiting. Aspirin administered with viral illness. Reye syndrome.