Tag aspirin
CCC Critical Care compendium 340

Salicylate Poisoning

Salicylate poisoning: mechanisms of toxicity: acid-base disturbance, uncoupling of oxidative phosphorylation, disordered glucose metabolism
CCC Critical Care compendium 340


Aspirin: antiplatelet agent; irreversible acetylation of cyclooxygenase -> blocks the production of prostaglandins from membrane phospholipids -> inactivation of platelet aggregation by arachidonic acid and collagen.