"The Dirty Dozen" common errors to avoid on discharging patients who are recovering from critical illness; co-authored by clinicians and researchers
Oxidative stress is refers an imbalance between production of reactive oxygen species and the protection of antioxidants, due to the accumulation of free radicals and/or the inability of antioxidants to counter their accumulation or effects.
GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)
Routine management in ICU involves avoiding complications of hyperglycaemia (infections) and hypoglycaemia (arrhythmias, neurological damage, cardiac events). Traditional goals have varied
Nutritional Assessment in Critical Illness: poor nutritional state is a common feature of critically ill patients, either pre-existing or as a result of the illness
There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.
Critical illness is associated with a spectrum of neurological failure (largely under-reported), including polyneuropathy, encephalopathy and long-term cognitive impairment after critical illness (LTCI-CI)
Transferring the Critically Ill: key principle is that the standard of care should not decrease during or after retrieval of a critically ill patient
In simple terms, pharmacodynamics is "how the drug effects the body" and pharmacokinetics is "how the body handles the drug"; changes also occur in obesity, pregnancy, old age and the very young which may each coexist with critical illness
The endothelial glycocalyx (EG) is a thin proteinaceous layer previously thought to be inert, that is now thought to play a key role in vascular integrity and function. The glycocalyx has potential as a novel therapeutic target