Oxidative stress is refers an imbalance between production of reactive oxygen species and the protection of antioxidants, due to the accumulation of free radicals and/or the inability of antioxidants to counter their accumulation or effects.
Reviewed and revised 31 December 2015 OVERVIEW Obesity is the chronic abnormal or excessive accumulation of fat in adipose tissue to the extent that health may be impaired degrees of obesity are defined by body mass index (BMI) OBESITY PARADOX…
GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)
OVERVIEW Vitamin D is a fat soluble vitamin with dermal synthesis being the major natural source Main clinically significant role is in maintaining calcium homeostasis and bone metabolism There is an increasing appreciation for its pleiotropic effects, including immunomodulatory and…
There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.
Critical illness is associated with a spectrum of neurological failure (largely under-reported), including polyneuropathy, encephalopathy and long-term cognitive impairment after critical illness (LTCI-CI)
In simple terms, pharmacodynamics is "how the drug effects the body" and pharmacokinetics is "how the body handles the drug"; changes also occur in obesity, pregnancy, old age and the very young which may each coexist with critical illness
The endothelial glycocalyx (EG) is a thin proteinaceous layer previously thought to be inert, that is now thought to play a key role in vascular integrity and function. The glycocalyx has potential as a novel therapeutic target
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