The Dirty Dozen
"The Dirty Dozen" common errors to avoid on discharging patients who are recovering from critical illness; co-authored by clinicians and researchers
Tag Critical Illness
Oxidative Stress in Critical Illness
Oxidative stress is refers an imbalance between production of reactive oxygen species and the protection of antioxidants, due to the accumulation of free radicals and/or the inability of antioxidants to counter their accumulation or effects.
Obesity and Critical Illness
Reviewed and revised 31 December 2015 OVERVIEW Obesity is the chronic abnormal or excessive accumulation of fat in adipose tissue to the extent that health may be impaired degrees of obesity are defined by body mass index (BMI) OBESITY PARADOX…
GI Drug Absorption in Critical Illness
GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)
Glucose Control in the Critically Ill
Routine management in ICU involves avoiding complications of hyperglycaemia (infections) and hypoglycaemia (arrhythmias, neurological damage, cardiac events). Traditional goals have varied
Nutritional Assessment in the Critically Ill
Nutritional Assessment in Critical Illness: poor nutritional state is a common feature of critically ill patients, either pre-existing or as a result of the illness
Vitamin D in Critical illness
OVERVIEW Vitamin D is a fat soluble vitamin with dermal synthesis being the major natural source Main clinically significant role is in maintaining calcium homeostasis and bone metabolism There is an increasing appreciation for its pleiotropic effects, including immunomodulatory and…
Genetics and Critical Illness
There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.
Long-term cognitive impairment in Critical Illness
Critical illness is associated with a spectrum of neurological failure (largely under-reported), including polyneuropathy, encephalopathy and long-term cognitive impairment after critical illness (LTCI-CI)
Transferring the Critically Ill
Transferring the Critically Ill: key principle is that the standard of care should not decrease during or after retrieval of a critically ill patient
Pharmacology and Critical Illness
In simple terms, pharmacodynamics is "how the drug effects the body" and pharmacokinetics is "how the body handles the drug"; changes also occur in obesity, pregnancy, old age and the very young which may each coexist with critical illness
Glycocalyx in Critical Illness
The endothelial glycocalyx (EG) is a thin proteinaceous layer previously thought to be inert, that is now thought to play a key role in vascular integrity and function. The glycocalyx has potential as a novel therapeutic target