Tag Critical Illness
CCC Critical Care compendium 340

The Dirty Dozen

"The Dirty Dozen" common errors to avoid on discharging patients who are recovering from critical illness; co-authored by clinicians and researchers
CCC Critical Care compendium 340

Oxidative Stress in Critical Illness

Oxidative stress is refers an imbalance between production of reactive oxygen species and the protection of antioxidants, due to the accumulation of free radicals and/or the inability of antioxidants to counter their accumulation or effects.
CCC Critical Care compendium 340

Obesity and Critical Illness

Reviewed and revised 31 December 2015 OVERVIEW Obesity is the chronic abnormal or excessive accumulation of fat in adipose tissue to the extent that health may be impaired degrees of obesity are defined by body mass index (BMI) OBESITY PARADOX…
CCC Critical Care compendium 340

GI Drug Absorption in Critical Illness

GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)
CCC Critical Care compendium 340

Vitamin D in Critical illness

OVERVIEW Vitamin D is a fat soluble vitamin with dermal synthesis being the major natural source Main clinically significant role is in maintaining calcium homeostasis and bone metabolism There is an increasing appreciation for its pleiotropic effects, including immunomodulatory and…
CCC Critical Care compendium 340

Genetics and Critical Illness

There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.
CCC Critical Care compendium 340

Pharmacology and Critical Illness

In simple terms, pharmacodynamics is "how the drug effects the body" and pharmacokinetics is "how the body handles the drug"; changes also occur in obesity, pregnancy, old age and the very young which may each coexist with critical illness
CCC Critical Care compendium 340

Glycocalyx in Critical Illness

The endothelial glycocalyx (EG) is a thin proteinaceous layer previously thought to be inert, that is now thought to play a key role in vascular integrity and function. The glycocalyx has potential as a novel therapeutic target