Alix Joffroy (1844 - 1908) was a French neurologist and psychiatrist. Eponymously affiliated with Joffroy sign in Graves ophthalmopathy
Joffroy sign (1893): absent wrinkling of the forehead when a patient in patients Graves Ophthalmopathy looks up with the head bent forwards.
Albrecht von Gräfe (1828 – 1870) was a German ophthalmologist. Founder of scientific ophthalmology, Graefe sign (1864)
Karl Stellwag von Carion (1823 – 1904) was an Austrian ophthalmologist. Eponym: Stellwag Sign (1869) in Graves orbitopathy
Dalrymple sign: Widened palpebral tissue (lid retraction) or lid spasm seen in thyrotoxicosis (Graves disease) by John Dalrymple (1852)
Time to review the descriptions and eponymythology of the forgotten signs associated with Graves orbitopathy - the signs of Dalrymple, Stellwag, von Graefe, Möbius and Joffroy...
Graves Ophthalmopathy: constellation of findings, apparent in 25-50% of patients with Graves disease. Robert Graves 1835
Graves disease: Autoimmune disease that affects the thyroid. A form of hyperthyroidism manifesting the triad of goitre, exophthalmos and pretibial myxoedema.
Robert James Graves (1796-1853) was an Irish physician. Graves disease (1835). Renowned polyglot with proficient linguistic skills and a talented artist