Paracetamol / Acetaminophen Update. Dr Angela Chiew – Australian Clinical Toxicologist and Emergency Staff Specialist
ACEM Primary Pharmacology of N-Acetyl-Cysteine: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
N-acetylcysteine (NAC) is the most widely used sulfhydryl donor in the treatment of paracetamol poisoning. Standard therapy consists of a series of three infusions given over 20 hours.
A case of paracetamol-induced hepatotoxicity with a discussion of the Schiodt scoring system for predicting paracetamol-induced liver failure.
N-acetylcysteine (NAC): glutathione supplementation ? protects the liver by maintaining and restoring glutathione levels or by acting as an alternate substrate for conjugation with -> detoxification of reactive metabolites.