Tag sepsis
CCC Critical Care compendium 340

Initial Management of Sepsis

Reviewed and revised 17 September 2019 OVERVIEW Initial management of sepsis and septic shock involves consideration of: resuscitation early administration of appropriate antibiotics following blood cultures early source control judicious fluid resuscitation, avoiding excess fluids noradrenaline for refractory hypotension (septic shock) inotropes…
CCC Critical Care compendium 340

Neutropaenic Sepsis

Febrile neutropaenia (or neutropaenic fever) is defined as: a single temperature measurement >=38.5C, or a sustained temperature >=38C for more than 1 hour; in a patient with a decreased absolute neutrophil count (ANC) of either <0.5 x 109/L, or <1 x 109/L with a predicted nadir of <0.5 x 109/L over the subsequent 48h
CCC Critical Care compendium 340

Surviving Sepsis Campaign Guidelines 2012

Reviewed and revised 8 January 2016 OVERVIEW The Surviving Sepsis Campaign (SSC) is a joint collaboration of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine that seeks to reduce mortality from severe sepsis and septic shock…
CCC Critical Care compendium 340

Corticosteroid Therapy for Shock

Corticosteroids are widely used in patients with refractory septic shock, as well as other selected causes of shock. Despite numerous trials, the role of corticosteroids in septic shock remains a controversial issue... still!
CCC Critical Care compendium 340

Sepsis Pathophysiology

OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK =…
CCC Critical Care compendium 340

Septic encephalopathy

Septic encephalopathy is brain dysfunction mediated by the septic inflammatory response, independent of other co-existent causes such as liver or renal dysfunction
CCC Critical Care compendium 340

Steroids and Septic Shock Literature Summaries

Bone R.C. et al (1987) “A controlled clinical trial of high dose methylprednisolone in the treatment of severe sepsis and septic shock” NEJM, 317:653-658 PMID 3306374 RCT n = 382 with sepsis and organ dysfunction methylprednisolone (30mg/kg) vs placebo-> no…