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Home | CCC | Atrial Natriuretic Peptide

Atrial Natriuretic Peptide

by Dr Chris Nickson, last update March 23, 2019

OVERVIEW

  • isolated from the right atrium
  • 28 aa peptide
  • potent diuretic/natriuretic effect on kidney + vasodilator effects on resistance & capacitance of blood vessels
  • released in response to atrial stretching (ie. fluid overload)

FUNCTIONS

  • vasodilation of afferent > efferent arterioles -> increased GFR
  • increased urinary Na+ & H2O excretion
  • relaxation of vascular smooth muscle -> vasodilation
  • inhibition of plasma renin activity
  • inhibition of aldosterone release
  • inhibition of ADH secretion by post-pituitary

References and Links

  • Witthaut R. Science review: natriuretic peptides in critical illness. Crit Care. 2004 Oct;8(5):342-9. Epub 2004 Jun 17. PMCID: PMC1065010.

CCC 700 6

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About Dr Chris Nickson

An oslerphile emergency physician and intensivist suffering from a bad case of knowledge dipsosis. Key areas of interest include: the ED-ICU interface, toxicology, simulation and the free open-access meducation (FOAM) revolution. @Twitter | INTENSIVE| SMACC

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