August Karl Gustav Bier

Biography

• Born November 24, 1861 in Helsen Waldeck, Germany
• 1881-1886 Studied medicine at the Universities of Berlin (’81), Leipzig (’82-83), and finally Kiel (’83-86)
• 1886-1888 Numerous medical posts including ship’s surgeon to South America (twice); a general practitioner in Gettorf, a small village outside of Kiel; and a voluntary doctor of the First Sailor Division in Kiel.
• 1888 – MD, University of Kiel defending thesis Kenntnis der Syphilome der äusseren Muskulatur; residency in surgery under the professor Friedrich Von Esmarch in Kiel. He became an assistant to Esmarch and supervised the changeover from the antiseptic to aseptic system in operating theatres
• 1889 – Performed the first spinal anaesthetic
• 1895 – Professor extraordinarius, University of Kiel
• 1903 – Professor of Surgery at Bonn
• 1905 – Married his first patient, Anna Esau with whom he had 5 children. Honorary Member of the Scottish Association for Surgeons; Honorary Doctor in Law Sciences at the University of Edinburgh. Cameron prize for his new concept to treat acute as well as chronic infections, especially tuberculosis, by hyperemia.
• 1907 – Chair of Surgery in Berlin
• 1908 – Described intravenous procaine analgesia (Bier Block)
• 1910 – President of the Deutsche Gesellschaft für Chirurgie [German Society of Surgeons]
• 1914 – Obergeneralarzt der Marine in Wilhelmshaven
• 1915 – Bier and Military physician Friedrick Schwerd developed the prototype M16 steel helmet for German troops in WW1. Offered much greater protection than the standard Kaiser Wilhelm helmet
• 1918 – Founded the Deutsche Sporthochschule für Leibesübungen, convinced that exercise is essential for good health. He was Rector from 1920 until it’s closure in 1932
• 1931 – Star of the Royal House of Hohenzollern
• 1932 – Retired from surgery to his 828 acre woodland estate in Sauen
• 1937 – Awarded the German National Prize for the Arts and Science [Deutscher Nationalpreis für Kunst und Wissenschaft], The German alternative to the Nobel Prize
• Awards: Five international doctorates; Roter Adlerorden II. Klasse mit Eichenlaub; Königlicher Kronen-Orden (Preußen) II. Klasse; Königlicher Kronen-Orden (Preußen) II. Klasse.
• Died March 12, 1949 aged 87

Medical Eponyms

Bier Block (1908)

On April 22, 1908 at the thirty-seventh Congress der Deutschen Gesellschaft für Chirurgie in Berlin, Bier demonstrated the new regional anaesthesia technique by performing a lower limb amputation and resection of an elbow. The procedure required minimal equipment; avoided a general anaesthetic; and provided a blood free surgical site.

An Esmarch Bandage was used to exsanguinate the limb. Following this, tourniquets were placed proximal and distal to the surgical site to keep to local anaesthetic within the desired area. An appropriate vein, such as the basilic, cephalic, or great saphenous is dissected (venae section) within the the isolated segment; appropriate ligatures placed; and a venous cannula inserted. Local anaesthetic was then injected intravenously (direkte Venenanästhesie) taking affect within minutes (originally 0.25% procaine was used by Bier), allowing the procedure to commence.

The distal tourniquet is removed when the desired anaesthetic effect achieved. With the procedure complete, and a safe amount of time elapsed, the proximal bandage can be removed with the return of sensation within minutes.

Bier presented a series of 134 cases in Ueber Venenanästhesie (1909) in which the anaesthetic effect was described as ‘good’ in 115; ‘satisfying’ in 14; and ‘insufficient’ in 5 patients. Following the Cameron Lecture delivered in Edinburgh on 20th July 1910, Bier published his first comprehensive analysis in English. However, this latter account is oft overlooked with the authors name misspelled as BEIR…

1909 – Bier’s assistant, Fritz Momburg (1870-1939), published a a modification of Bier’s technique to reduce the pain caused by the proximal tourniquet (1). A third bandage (3) was placed around the anaesthetised arm, distal to the first tourniquet, allowing the first tourniquet to be removed and alleviate pain.

1954 – The Bier block technique had fallen in disuse due to its cumbersome technique, and the fear of possible early liberation of local anaesthetic into the bloodstream. Brazilian Flavio Kroeff-Pires (1917- ) published his experiences with the IVRA technique in 1954 and both modernized and popularized the technique using 0.5% procaine.

1963 – It was later simplified by Charles McKinnon Holmes (1935 – 2020). Holmes used a single sphygmomanometer cuff (high, proximal, and inflated to above the systolic blood pressure); a fine needle into a convenient vein (typically the dorsum of the hand); and 0.5% lignocaine as anaesthetic. He described a series of 30 patients, concluding the technique to be simple, safe and not requiring special training or extensive experience.

Since Bier’s initial introduction of this method of anaesthesia it has been substantially modified and protocols for Biers block differ depending on the country, local protocols and which limb is undergoing the procedure.

Key Medical Attributions

Spinal anaesthesia

During his time at Kiel, Bier worked with Heinrich Quincke (1842-1922), who had safely performed lumbar punctures as an investigative procedure (1891), and injected drugs for the treatment of tuberculosis. This inspired Bier to identify that cocaine could be injected directly into cerebrospinal fluid to produce analgesia.

1889 – Bier performed the first spinal anaesthetic using 3mL of 0.5% solution of cocaine on a 34 year old man with disseminated tuberculosis who required partial amputation of the leg. According to Bier, the man reported having no feeling in the lower half of his body, remained conscious throughout the operation and informed Bier that he had not felt any pain. Bier also noted that the patient could not move his limbs throughout the procedure

After successfully administering six spinal blocks, Bier allowed his junior colleague, Otto Hildebrandt (1868 – 1954) to inject 2 mL of 1% cocaine solution into his own (Bier’s) spinal fluid. Unfortunately the syringe did not fit the needle, causing the cocaine and his CSF to leak out. He then performed a successful spinal anaesthetic on Hildebrandt whereby analgesia of the lower limbs occurred within eight minutes.

These experiments proved to us that an exceedingly small quantity of cocaine (0.005gm) injected into the intrathecal space can narcotise two-thirds of the body to such a degree that major surgery can be performed painlessly. Loss of sensation develops in the legs 5-8 minutes after injection.

…cocainization of the spinal cord could be used for painless surgery. It can serve this purpose only if it is associated with less danger and discomfort than general anaesthesia

Bier 1899

Both Bier and Hildebrandt suffered severe Post dural puncture headache (PDPH) which lasted almost a week. Bier hypothesised:

Both of us doctors suffered the worst reactions, probably because we were careless with our bodies. Instead of lying down after the lumbar puncture and the cocaine injection, we continued our daily routine, we drank and smoked more than was beneficial, and we did our work the following day as usual. Regarding the after effects, we have to decide the following question: were they caused by the poisonous effects of cocaine, or did the injection of a foreign substance into the intrathecal canal irritate the central nervous system?

Bier 1899

Hyperemic therapy (Hyperämie als Heilmittel)

Bier was intrigued by the reactive hyperemia phenomenon and relief of symptoms following the application of an Esmarch bandage. Bier used his hyperemia method to manage tuberculosis, elephantiasis, parotitis, inflammation of joints, and other conditions. He first published his findings on Heilwirkung der Hyperaemie in 1897.

Bier was convinced of the hyperemic theory of treatment and tested the effects on himself. He applied a tourniquet around his upper arm for 10 hours and also one around his neck for a whole night resulting in vertigo, pulsating headache, swollen eyelids, and red eyes for several hours.

Major Publications

• Bier A. Beiträge zur Kenntnis der Syphilome der äusseren Muskulatur. Thesis, Kiel, 1888
• Bier A. Heilwirkung der Hyperaemie. Münchener medizinische Wochenschrift, 1897; 32(44): 875-880
• Bier A. Versuche über Cocainisirung des Rückenmarkes. Deutsche Zeitschrift für Chirurgie 1899; 51: 361. [Translated: Experiments Regarding the Cocainization of the Spinal Cord. Survey of Anesthesiology 1962; 6: 352–358]
• Bier A. Hyperämie als Heilmittel. Münchener medizinische Wochenschrift 1897; 32: 44.
• Bier A. Hyperämie als Heilmittel. 1903 [Translated: Belch GM. Hyperemia as a therapeutic agent. 1905] [2e 1907]
• Bier A. Ueber einen neuen Weg Localanästhesie an den Gliedmassen zu erzeugen. Arch Klin Chir, 1908; 86: 1007-1016. [Bier block]
• Bier A. A new method for local anaesthesia in the extremities. Annals Of Surgery, 1908; 47: 780.
• Bier A, Meyer W, Schmieden V. Bier’s hyperemic treatment : in surgery, medicine, and the specialties: a manual of its practical application. 1908
• Bier A. Ueber Venenanasthesia. Berliner Klinische Wochenschrift 1909; 46(11): 477-489 [Bier block]
• Beir A. On local anaesthesia, with special reference to vein anaesthesia. Edin Med J, 1910; 5: 103-123.
• Bier A, Braun H, Kümmell H. Chirurgische operationslehre. 1920 [Vol II, III, IV, V]
• Bier A. Wie sollen wir uns zu der Homöopathie stellen? [How should we approach homeopathy?] 1925
• Bier A. Die Seele [The soul]. 1940
  

References

Biography

• Vogeler K. August Bier, Leben und Werk. 1942
• Goerig M et al. The versatile August Bier (1861-1949), father of spinal anesthesia. J Clin Anesth. 2000; 12(7): 561-9.
• Van Zundert A, Goerig M. August Bier 1861-1949. A tribute to a great surgeon who contributed much to the development of modern anesthesia on the 50th anniversary of his death. Reg Anesth Pain Med. 2000; 25(1): 26-33.
• Bacon DR. August Bier’s legacy: more than just a pioneer in regional anesthesia? J Clin Anesth. 2000; 12(7): 501-2.
• Barkey A. August Bier. The surgeon who planted trees and invented the steel helmet. Documentary by Uli Aumüller. 2009
• Maltby R. August Bier. In: Notable Names in Anaesthesia. The Choir Press; 2013: 19-21
• Erjavic N. August Karl Gustav Bier (1861–1949). Embryo Project Encyclopedia. 2017
• Bibliography. Bier, August 1861-1949. WorldCat Identities

Eponymous terms

• Momburg F. Zur Venenanästhesie Bier’s. Zentralblatt für Chirurgie 1909; 36(2): 1413–1414.
• Holmes CM. Intravenous regional analgesia. A useful method of producing analgesia of the limbs. Lancet. 1963; 281(7275): 245-247.
• Hilgenhurst G. The Bier block after 80 years: a historical review. Reg Anesth. 1990 Jan-Feb;15(1):2-5.
• Marx GF. The first spinal anesthesia. Who deserves the laurels? Reg Anesth. 1994 Nov-Dec;19(6):429-30.
• dos Reis A Jr. Eulogy to August Karl Gustav Bier on the 100th anniversary of intravenous regional block and the 110th anniversary of the spinal block. Rev Bras Anestesiol. 2008 Jul-Aug;58(4):409-24.
• van Zundert A, Helmstädter A, Goerig M, Mortier E. Centennial of intravenous regional anesthesia. Bier’s Block (1908-2008). Reg Anesth Pain Med. 2008 Sep-Oct;33(5):483-9.
• Bateman BT, Alston TA. Commonly used eponyms in anesthesia. J Clin Anesth. 2009 Feb;21(1):67-71
• Jacob. A Short History of the German Steel Helmet of the Great War. 2014
• Löser B, Petzoldt M, Löser A, Bacon DR, Goerig M. Intravenous Regional Anesthesia: A Historical Overview and Clinical Review. J Anesth Hist. 2019 Jul;5(3):99-108.

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