Hepatic venous outflow obstruction causing portal hypertension
1845 – George Budd references Lambron in 1842 to be the first to describe inflammation of the portal vein secondary to mechanical obstruction [p136 1845]. Within the same section IV of ‘On diseases of the liver‘ Budd discusses in depth hepatic venous thrombosis associated with hepatomegaly, a collateral circulation, and ascites.
1899 – The syndrome was re-described with further clinical and pathological observations by Hans Chiari and is now referred to as the Budd-Chiari syndrome
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