Hans Chiari (1851-1916) was an Austrian pathologist.
He made important contributions in endocrinology, cardiology and neurology and became known for his teaching skills as a Professor in Prague.
- Born 4 September 1851 Vienna, Austria, into a family of physicians.
- Studied medicine in Vienna and worked as an assistant at the Vienna Institute of Pathology
- Graduated 1875
- Appointed Professor Extraordinarius at the German University in Prague, 1882
- Died 6 May 1916 Strassburg following a throat infection
Budd–Chiari syndrome (1899)
Hepatic venous outflow obstruction causing portal hypertension.
Whilst working as a pathologist in Prague, Chiari described three patients with hepatic vein thrombosis, together with a review of the literature including another seven patients. Chiari advanced Budd’s early description clinical and pathological correlations terming the condition ‘phlebitis obliterans’. Pathologically, the livers appeared to be congested, atrophic, and diffusely necrotic, with congestion of the spleno-portal circulation and large volume ascites.
Arnold–Chiari malformation (1891, 1894, 1896) – descent of the cerebellar tonsils and vermis, medulla and pons, with associated elongation and displacement of the fourth ventricle. Frequently occurs with hydrocephalus and also associate with myelomeningocele. Chiari credited others in his writing regarding the type 2 malformation – namely John Cleland and Julius Arnold, the former of whom had briefly described similar pot-mortem findings in a child in 1883.
Chiari malformations – abnormalities of the brain stem and cerebellum identified by Chiari on post-mortems. Type 1 (1891) – peg-like elongation of the cerebellar tonsils into the spinal canal through the foramen magnum; Type 2 aka Arnold Chiari malformation and Type 3 and 4.
Chiari network – mobile net-like connections between the valve of the coronary sinus and the valve of the inferior vena cava. An anatomical variant, usually of no clinical significance.
- Chiari H. Ueber Veränderungen des Kleinhirns infolge von Hydrocephalie des Grosshirns. Deutsche medizinische Wochenschrift 1891;17(42): 1172–1175 [Chiari malformations type 1 and type 2 aka Arnold–Chiari malformation]
- Chiari H. Erfahrungen über Infarktbildungen in der Leber des Menschen. Zeitschrift für Heilkunde, 1898; 19: 475-512.
- Chiari H. Ueber die selbständige Phlebitis obliterans der Hauptstämme der Venae hepaticae als Todesursache. Beiträge zur pathologischen Anatomie und zur allgemeinen Pathologie. 1899; 26: 1-18. [Beiträge zur Pathologie 1976; 158(1): 31-41] [Budd–Chiari syndrome]
- Chiari H. Die pathologische Anatomie im 19. Jahrhundert und ihr Einfluss auf die äussere Medizin. 1900
- Chiari H. Pathologisch-anatomische Sektionstechnik. 1907
- Pearce JM. Arnold chiari, or “Cruveilhier cleland Chiari” malformation. J Neurol Neurosurg Psychiatry. 2000; 68(1): 13.
- Loukas M, Noordeh N, Shoja MM, Pugh J, Oakes WJ, Tubbs RS. Hans Chiari (1851-1916). Childs Nerv Syst. 2008; 24(3): 407-9
- Tubbs RS, Cohen-Gadol AA. Hans Chiari (1851-1916). J Neurol. 2010; 257(7): 1218-20
- Bibliography. Chiari, Hans 1851-1916. WorldCat Identities
the person behind the name