Karel Rokitansky

Karel (Carl von) Rokitansky (1804-1878)

Karel Freiherr von Rokitansky (1804-1878) was a Czech pathologist, physician and politician

Rokitansky, described as the founder of clinical pathology. Premier pathologist of the ‘Allgemeines Krankenhaus,’ and leader of the ‘Dreigestirn’ with Joseph Škoda (1805–1881); and Ferdinand von Hebra (1816–1880). They were responsible for the revival of Vienna as the great medical center of the world in the mid-19th century


Biography
  • Born 19 February 1804 in Hradec, Králové (Königgrätz)
  • 1828 – Graduated medicine, University of Vienna
  • Pathologist “Allgemeines Krankenhaus”
  • 1875 – Rokitansky’s final publication was the monograph Die Defecte der Scheidewände des Herzens [The Defects of the Heart Septum]. His observations of 24 patients with VSD; 20 with ASD; description of the evolution of chicken embryos; and of the origin of heart malformations.
  • Died 23 July 1878

Medical Eponyms

Mayer-Rokitansky-Küster syndrome: (1838) Syndrome characterised by congenital absence of vagina, primary amenorrhoea, rudimentary cornua uteri and morphologically normal ovaries and Fallopian tubes situated on the pelvic sidewall. Normal ovulation; normal breast development; normal body and hair.


Rokitansky disease (1842) (Budd-Chiari syndrome): obstruction of hepatic veins by a blood clot in liver cirrhosis. Hans Chiari (1851 – 1916) was assistant to Rokitansky in Vienna 1874-1875. Together they studied and referred to the appearance of the syndrome that leads from the liver cirrhosis and ascites and results in the destruction of hepatic veins as a result of clot or mass


Rokitansky–Aschoff sinuses (1842, 1905)

Rokitansky-Aschoff sinuses diverticula of the gallbladder wall which may be microscopic or macroscopic. They are the result of hyperplasia and herniation of epithelial cells through the fibromuscular layer of the gallbladder wall and are usually referred to as adenomyomatosis of the gallbladder. [aka *Luschka’s sinuses, crypts, glands, or ducts]


Rokitansky-Maude Abbott syndrome (1875, 1924): Rare congenital heart disease characterized by persistence of the interatrial ostium primum associated with a cleft of the internal valve of the mitral orifice, thus separated into two half-valves, anterior and posterior, each inserted on a special pillar.

In 1924, Maude Abbott (1869 – 1940) published on “Persistent ostium primum with cleavage of anterior mitral segment and deformity of tricuspid septal cusp. No cyanosis.”

The auricular septum presents a valvular patency of the foramen ovale and ends below in a crescentic free border which forms the upper boundary of a defect 3 by 2 cm. large, the lower border of which is formed by the overlapping upper halves of the completely divided anterior mitral segment. From an infant which presented a peculiar murmur over the precordium and was the subject of mongolian idiocy. Death at 10 months from bronchopneumonia.

[Abbott 1924; 10: 111] [Abbott 1936; Plate XIV: Fig 8]

Abbott further commented that:

Cleavage of the anterior of the mitral valve was described by Rokitansky as a practically constant feature in all cases of persistent ostium primum, and it has been present in all the cases that have come under our observation

Abbott 1924; 10: 116

Rokitansky syndrome (superior mesenteric artery syndrome)

In 1842 Rokitansky described a type of acute dilatation of the stomach due to compression of the duodenum by the root of the mesentery and its vessels and nerves. In the 3rd edition (1861-1863) in speaking of intestinal incarceration due to pressure of one part of the intestine or it’s mesentery on another, so as to compress it against the posterior abdominal wall, he says:

Herewith belongs the compression of the lower transverse section of the duodenum by the mesentery of the small intestine and especially, by the superior mesenteric artery and nerves contained in the root of the mesentery.

Rokitansky 1863

Key Medical Contributions

Rokitansky Humoral Pathology (Krasenlehre) (1848)

In 1848 Rokitansky proposed a hypothesis he called “Krasenlehre” with the site of the disease state being somewhere within the blood fluid embracing all organs. He postulated that atherosclerosis follows initial fibrin deposition on the vessel wall. The idea was ahead of its time, before organic chemistry or biochemistry came into existence. The wrath of Virchow ensued and Rokitansky removed the theory from the second edition of ‘Lehrbuch der pathologischen Anatomie’ in 1855.

The theory was renewed in the 1940’s and 50’s and sometimes referred to as the Rokitansky-Duguid-Astrup hypothesis

Rokitansky suggested that fibrinous deposits were produced on the vessel wall by an effect of the exudate released from injured tissue on some components in the blood. This concept was one of the main reasons for Virchow’s rejection of Rokitansky’s idea, since he thought blood clotting was caused by oxygen. Intuitively, Rokitansky reached views concerning physiological processes which forecast observations made many years later. His concepts were developed before fibrinogen was known as an entity, before thrombin was known, before the clot promoting effect of the tissue extract was known, and more than sixty years before its role as an activator and its difference from thrombin was revealed by Morawitz and Fuld and Spiro. Tage Astrup 1958


Major Publications

Controversies

Alternate names in literature: First name as ‘Karel’, ‘Karl’ or ‘Carl’; Surname as ‘Rokitanski’ or ‘Rokitansky’;

Title most often as ‘Karl Freiherr von Rokitansky’. Rokitansky became a member for life of the House Lords of the Imperial Council in 1967 and elevated to knighthood in 1874 with the title Freiherr (Baron) von Rokitansky


References

eponymictionary CTA

eponym

the person behind the name

Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM with a passion for rugby; medical history; medical education; and informatics. Asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | vocortex |

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