The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
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Fluid responsiveness is an increase of stroke volume of 10-15% after the patient receives 500 ml of crystalloid over 10-15 minutes (as defined by Paul Marik). The definitive test for fluid responsiveness is a Fluid challenge
High protein hypocaloric feeding is preferred for critically ill obese patients (supported by SCCM/ ASPEN joint Consensus statement)
Obesity affects all four aspects of pharmacokinetics. As drug administration based on total body weight can result in in underdosing or overdosing, depending on the characteristics of the drug, weight-based dosing scalars must be considered. Lean body weight is the optimal scalar for most IV opioids and anaesthetics
Reviewed and revised 31 December 2015 OVERVIEW Obesity is the chronic abnormal or excessive accumulation of fat in adipose tissue to the extent that health may be impaired degrees of obesity are defined by body mass index (BMI) OBESITY PARADOX…
Drug withdrawal in ICU is more common than generally appreciated.
Haemoperfusion: Renal replacement therapy (RRT) using an adsorbent cartridge to remove circulating toxins
Extracorporeal Elimination recommended for the following intoxications: methotrexate, procanamide, lithium, metformin, ethanol, methanol, ethylene glycol, salicylates, theophylline, sodium valproate.
The role for digestive tract decontamination depends on: severity of poisoning; time from ingestion; risk of intervention
Monoamine Oxidase Inhibitor (MAOI) Toxicity produces a hyperadrenergic syndrome from inability to inactivate noradrenaline; may contribute to serotonin toxidrome
Retrospective studies are designed to analyse pre-existing data, and are subject to numerous biases as a result. Types of retrospective studies include: case series; retrospective cohort studies; case-control studies
Leukotriene Receptor Antagonists example is Montelukast