Aprotinin
Aprotinin: antifibrinolytic; single chain polypeptide which occurs naturally in bovine lung and other tissues; inhibits fibrionlysis via inactivation of free plasmin
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Aspirin
Aspirin: antiplatelet agent; irreversible acetylation of cyclooxygenase -> blocks the production of prostaglandins from membrane phospholipids -> inactivation of platelet aggregation by arachidonic acid and collagen.
Benzylpenicillin
Benzylpenicillin: penicillin antibiotic; inhibition of cell wall synthesis
Bosentan
Bosentan: dual endothelin receptor antagonist; competitive antagonism of endothelin-1 (pulmonary vasoconstrictor) at the endothelin receptors -> decreases PVR
Ceftriaxone
Ceftriaxone: 3rd generation cephalosporin; inhibition of cell wall synthesis: gram –ve rods (except Pseudomonas); gram +ve cocci (except Methicillin resistant and group D streptococci)
Oculocephalic and oculovestibular reflexes
Oculocephalic and oculovestibular reflexes are primarily used to determine whether a patient's brainstem is intact (e.g. coma or brain death assessment)
Guillain-Barré Syndrome (GBS)
Guillain-Barré Syndrome (GBS) is the most common and most severe acute paralytic neuropathy, consisting of multiple variants with distinct clinical and pathological features
Hearing Loss in ICU
Hearing Loss in ICU is an under-appreciated problem: Conductive (external ear; middle and inner ear; Sensorineural)
Horner Syndrome
Horner Syndrome = unilateral interruption of ascending cervical sympathetic innervation eye and face.
HSV Encephalitis
HSV Encephalitis: severe viral infection of the central nervous system, caused by a herpes simplex virus and usually localised to the temporal and frontal lobe; most commonly identified cause of infectious encephalitis; 5-10% of encephalitis cases worldwide