Ten Commandments of Clinical Research
The Ten Commandments of Clinical Research according to Stoller and Mireles-Cabodevila.
Category Clinical Research
Inattentional blindness, unintentional consequences
We are all at risk of missing the giant man in the gorilla suit every day in ED.
Is the Peer Reviewed Journal Dead?
Tony Brown, until recently Editor of Emergency Medicine Australasia, gives us his answer to the question 'Is the Peer Reviewed Journal Dead?'
The Wisdom of Crowd Review
Almost immediately after finishing ‘Time to publish then filter?’ - a post that highlighted a recent editorial in the BMJ outlining the need for an effective system of post-publication peer revie
Time to publish then filter?
I came across this post while getting up to speed with Critical Insight, a UK-based online blog-come-journal club. It had a link to a recent BMJ editorial by David Schriger and Douglas Altman — you may remember David Schriger from…
The Wilyman PhD
My thoughts on Judy Wilyman's overly wordy collation of the global anti-vaccination lobby arguments, wrapped up in a 390 page opinion piece (sorry, pHD)
Case Reports and Case Series
Case reports and case series are considered relatively low level evidence; despite this they have a role in EBM - they are often the first line of evidence, where discovery begins
Animal and laboratory studies
Animal and laboratory studies form the lowest level of evidence for informing clinical decisions
Quantitative Data Types and Tests
Quantitative data is that which can be expressed numerically and is associated with a measurement scale; not all numbers constitute quantitative data (e.g. tax file number!)
Logistic regression analysis
Logistic regression analysis is used to predict a dependent binary outcome (yes/no, dead/alive) based on one or more predictor variables
Randomisation
Randomisation is the process of assigning clinical trial participants to treatment groups such that each participation has a known (usually equal) chance of being assigned to any of the groups
Early Stopping of Trials
Reviewed and revised 26 August 2015 OVERVIEW Clinical trials are planned to stop when one of the following is reached sample size event count length of follow up goal scheduled date of closure Unplanned early stopping of trials may occur…