Phases of clinical research are the steps taken to gather evidence to determine whether a novel intervention or treatment is safe and effective for clinical use
Propensity analysis refers to statistical methods used to control for treatment selection bias in observational studies
Clinicians must be able to critically appraise clinical trials to determine their internal validity. Trials should adhere to the CONSORT statement (CONsolidated Standards of Reporting Trials)
OVERVIEW The Fragility Index is the minimum number of patients whose status would have to change from a nonevent to an event that is required to turn a statistically significant result to a non-significant result The smaller the Fragility Index, the more fragile the trial’s outcome The Fragility Index is a useful metric for demonstrating how easily […]
Confounding involves error in the interpretation of what may be an accurate measurement by attributing it to the wrong cause. A confounder is a factor that is prognostically linked to the outcome of interest and is unevenly distributed between the study groups
Incidence = number of individuals who develop a disease in a given period of time. Prevalence = the current number of cases in a given population
Measures of Central Tendency; these indices allow a sample or population to be summarised using a single value.
An odds ratio (OR) is a measure of association between an exposure and an outcome. The OR represents the odds that an outcome will occur given a particular exposure, compared to the odds of the outcome occurring in the absence of that exposure.
It is unethical and a waste of time and resources to embark on a study when there is a high chance of a false negative result (Type II error). The commonest cause of this is having a sample size that is too small
Qualitative data consists of categorical measurements determined by description rather than a numerical measurement