One of the first signs of vertebral metastases is disappearance of the pedicle on the AP X-ray. This is known as the 'absent pedicle' or 'winking owl sign'.
Network Five Emergency Medicine Journal Club Episode 7 - Oncology reviewing papers on frailty screening, Dexmedetomidine and immune checkpoint inhibitors
Febrile neutropaenia (or neutropaenic fever) is defined as: a single temperature measurement >=38.5C, or a sustained temperature >=38C for more than 1 hour; in a patient with a decreased absolute neutrophil count (ANC) of either <0.5 x 109/L, or <1 x 109/L with a predicted nadir of <0.5 x 109/L over the subsequent 48h