3.1 With regards to antibiotic dosing. Look at the diagram below, representing antibiotic drug concentration versus time, and answer the questions below:
- a) What does “A” represent? Name one class of antibiotic for which this is important with regards to dosing.
- b) What does “B” represent? Name one class of antibiotic for which this is important with regards to dosing.
- c) What does “C” represent? Name one class of antibiotic for which this is important with regards to dosing.
3.2 List the factors that result in failed resolution of sepsis despite antibiotic therapy.
Answer and interpretation
3.1 a) C MAX: Maximum concentration Aminoglycosides
3.1 b) AUC > MIC: Area under the curved where drug concentration is greater than MIC Quinilones
3.1 c) T>AUC above MIC: Time greater than Area under the curved where concentration is greater than MIC
- Wrong antibiotic choice
- Delayed administration of antibiotics
- Inadequate source control
- Inadequate antimicrobial blood levels
- Inadequate penetration of the antimicrobial to the target site, Antimicrobial neutralization or antagonism,
- Superinfection or unsuspected secondary bacterial infection, Non-bacterial infection
- Non-infectious source of illness
Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. He is also a Clinical Adjunct Associate Professor at Monash University. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives.
After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education.
He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. He is one of the founders of the FOAM movement (Free Open-Access Medical education) and is co-creator of litfl.com, the RAGE podcast, the Resuscitology course, and the SMACC conference.
His one great achievement is being the father of three amazing children.
On Twitter, he is @precordialthump.