CICM SAQ 2014.2 Q3
Question
3.1 With regards to antibiotic dosing. Look at the diagram below, representing antibiotic drug concentration versus time, and answer the questions below:
- a) What does “A” represent? Name one class of antibiotic for which this is important with regards to dosing.
- b) What does “B” represent? Name one class of antibiotic for which this is important with regards to dosing.
- c) What does “C” represent? Name one class of antibiotic for which this is important with regards to dosing.
3.2 List the factors that result in failed resolution of sepsis despite antibiotic therapy.
Answers
Answer and interpretation
3.1 a) C MAX: Maximum concentration Aminoglycosides
3.1 b) AUC > MIC: Area under the curved where drug concentration is greater than MIC Quinilones
3.1 c) T>AUC above MIC: Time greater than Area under the curved where concentration is greater than MIC
Penicillins, Carbenepenems
3.2
- Wrong antibiotic choice
- Delayed administration of antibiotics
- Inadequate source control
- Inadequate antimicrobial blood levels
- Inadequate penetration of the antimicrobial to the target site, Antimicrobial neutralization or antagonism,
- Superinfection or unsuspected secondary bacterial infection, Non-bacterial infection
- Non-infectious source of illness
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CICM
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