Delivery of Beta-2-Agonists in Intubated Patients
Delivery of Beta-2-Agonists in Intubated Patients. Need to consider: dose; side effect profile; effectiveness; cost
Dexmedetomidine
Dexmedetomidine: alpha 2 agonist; sedoanalgesia;
Dipyridamole
Dipyridamole: anti-platelet + vasodilator. Potentiates the effect of prostacyclin or by inhibiting phosphodiesterase enzyme activity -> increase intracellular cAMP; inhibits cellular uptake of adenosine -> more available to act on coronary vessels -> vasodilation
Post Operative Confusion
OVERVIEW RISK FACTORS CAUSES Anaesthetic Surgical INVESTIGATIONS MANAGEMENT Resuscitate Electrolytes and Acid-base Specific Therapy Underlying Cause References and Links
PRES
Posterior reversible encephalopathy syndrome (PRES) is a syndrome of 'cephalgia, convulsions, confusion, and vision loss' (CCCV) typically in the context of severe hypertension
Dobutamine
Pharmacology of dobutamine, a synthetic catecholamine used as an inotrope as it is a direct-acting moderately selective β1 adrenergic agonist
Dopamine
Dopamine: naturally occurring catecholamine; dopamine and adrenoreceptor agonist; immediate precursor to noradrenaline
Epidural Complications
Epidural Complications: Catheter related; or drug related
Flumazenil
Flumazenil: benzodiazepine antagonist; competitive antagonist that act on the benzodiazepine receptor
Frusemide
Frusemide: loop diuretic, known as furosemide in North America
GI Drug Absorption in Critical Illness
GI Drug Absorption in Critical Illness; multi-factorial determinants influence the bioavailability of drugs; governed by factors altering transport of substances across cell membranes (diffusion, active transport, ultrafiltration)
Gentamicin
Gentamicin; aminoglycoside; irreversible binding to bacterial ribosomal proteins -> inhibits protein synthesis; Antimicrobial cover: gram negative rods (including Pseudomonas)