Pharm 101: Vitamin K

Class

Vitamin


Pharmacodynamics
  • Confers biologic activity upon factors II (prothrombin), VII, IX and X by participating in their postribosomal modification
  • Two forms:
    • Vitamin K1 is found in food, primarily green leafy vegetables
    • Vitamin K2 synthesised by intestinal bacteria
  • Clinical uses:
    • Reversal of warfarin anticoagulation, prevention of haemorrhagic disease of new born
    • IV or PO Vitamin K1 is available clinically
    • IV administration should be slow as rapid infusion can cause dyspnoea, chest and back pain, and death

Reversal of warfarin anticoagulation
  • Warfarin prevents reductive metabolism of inactive vitamin K to active form so produces biologically inactive VII, IX, X, prothrombin, protein C and S
  • Vitamin K confers biologic activity upon factors II, VII, IX, X by participating in their postribosomal modification
  • Re-establishes normal activity of vitamin K dependent clotting factors II, VII, IX, X
  • 6-24 hours for effect

Further reading

References

Pharm 101 700

Pharmacology 101

Top 200 drugs

MBBS (UWA) CCPU Emergency Medicine Trainee with interests in medical education, ECG interpretation, and the use of point-of-care ultrasound in the undifferentiated patient. Co-author of the LITFL ECG Library | Twitter

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.