Pharm 101: Vitamin K

Class

Vitamin


Pharmacodynamics
  • Confers biologic activity upon factors II (prothrombin), VII, IX and X by participating in their postribosomal modification
  • Two forms:
    • Vitamin K1 is found in food, primarily green leafy vegetables
    • Vitamin K2 synthesised by intestinal bacteria
  • Clinical uses:
    • Reversal of warfarin anticoagulation, prevention of haemorrhagic disease of new born
    • IV or PO Vitamin K1 is available clinically
    • IV administration should be slow as rapid infusion can cause dyspnoea, chest and back pain, and death

Reversal of warfarin anticoagulation
  • Warfarin prevents reductive metabolism of inactive vitamin K to active form so produces biologically inactive VII, IX, X, prothrombin, protein C and S
  • Vitamin K confers biologic activity upon factors II, VII, IX, X by participating in their postribosomal modification
  • Re-establishes normal activity of vitamin K dependent clotting factors II, VII, IX, X
  • 6-24 hours for effect

Further reading

References

Pharm 101 700

Pharmacology 101

Top 200 drugs

MBBS (UWA) CCPU (RCE, Biliary, DVT, E-FAST, AAA) Emergency Medicine Advanced Trainee in Melbourne, Australia. Special interests in diagnostic and procedural ultrasound, medical education, and ECG interpretation. Editor-in-chief of the LITFL ECG Library. Twitter: @rob_buttner

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.