Ethylene glycol inebriation
A 5 year-old boy is 'off his face' after drinking what looked like a nice bottle of cordial. It was actually radiator coolant. You are called for advice.
Tag HAGMA
Anion Gap
OVERVIEW Anion Gap = Na+ – (Cl- + HCO3-) The Anion Gap (AG) is a derived variable primarily used for the evaluation of metabolic acidosis to determine the presence of unmeasured anions The normal anion gap depends on serum phosphate…
Metformin-associated Lactic Acidosis
Metformin use is associated with lactic acidosis, but it remains controversial as a disease entity
Metabolic Acidosis
a metabolic acidosis is an abnormal primary process or condition leading to an increase in fixed acids in the blood -> resulting in a fall in arterial plasma bicarbonate
Metabolic Acidosis Evaluation
A metabolic acidosis is a process which, if uncorrected, would lead to an acidaemia. It is usually associated with a low bicarbonate concentration (or total CO2), but an acidosis may be masked by a co-existing metabolic alkalosis.
Ketoacidosis
Ketoacidosis is a high anion gap metabolic acidosis due to an excessive blood concentration of ketone bodies (keto-anions).
Pyroglutamic Acidosis
Pyroglutamic acidosis is a rare cause of high anion gap metabolic acidosis (HAGMA). When glutathione levels are low, the activity of γ-glutamyl cyclotransferase is increased, resulting in pyroglutamic acid accumulation in glutathione-depleted states
D-Lactic acidosis
D-Lactic acidosis aka D-lactic encephalopathy. Rare cause of high anion gap metabolic acidosis (HAGMA), typically occurs in patients short bowel syndrome or following jejuno-ileal bypass surgery
Hypernatraemia and Acidosis
A 20 year old male presents with 3 days of lethargy and generalised malaise. He is confused and looks very unwell. Can sort out this metabolic muddle?
Staph Sepsis Acidosis
You are asked to review a 73 year old lady who is in hospital for treatment of septic arthritis affecting a prosthetic right hip joint inserted 5 years earlier.
Metabolic Mayhem a Headache
An 87 year old female presented with a subarachnoid haemorrhage. GCS 8/15. Can you figure out her acid-base disturbance?
another bubble of trouble…
the case. 43 year old female is brought into your resuscitation bay by the paramedics. She has a 2 day history of vomiting and diarrhoea on the background of type 2 diabetes and alcohol abuse. Her son is concerned that…