William Ganz

Biography

• Born on 7th January 1919, Košice, Czechoslovakia
• 1937 – Began medical studies at Charles University, Prague. 1938 Munich agreement made Kosice part of Hungary and Vilem was made a foreigner in Prague and had to return to his hometown, renamed Kassa at the time. He was drafted into Hungarian forced-labor camp
• 1944 – Escaped Nazi persecution at Auschwitz by using false documents to travel to Budapest where he met his wife Magda
• 1947 – Graduated at the top of his class, completing his medical studies at Charles University, Prague. Here Vilem worked with Arnost Fronek to engineer vascular catheters and pioneered the thermodilution method for measuring blood flow⁵
• 1966 – Migrated to Los Angeles, United States of America. Worked with Jeremy Swan and Edwards Laboratory to develop the Swan – Ganz catheter
• 1970 – Jeremy Swan and William Ganz et al. publish report: Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter.
• Died 11th November, 2009

Key Medical Attributions:

• Ganz worked with Arnost Fronek to engineer vascular catheters and pioneered the thermodilution method for measuring blood flow, Charles University, Prague
• Ganz also founded studies of human coronary circulation through the development of the coronary sinus thermodilution method, Cedars-Sinai Medical Centre
• He was also a leader in the advent of thrombolysis in the treatment of acute myocardial infarction, Cedars-Sinai Medical Centre

Medical Eponyms

Swan-Ganz catheter – pulmonary artery catheter (1970)

Pictured below is the “extruded polyvinyl-chloride catheter 1.7mm in outer diameter” with the balloon tipped catheter and “attached to a strain-gauge catheter.” The pulmonary artery was accessed via “antecubital-vein cutdown” during the inception

Major Publications

• Swan HJ, Ganz W, Forrester J, Marcus H, Diamond G, Chonette D. Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter. N Engl J Med. 1970 Aug 27;283(9); 447-51.
• Ganz V, Hlavova A, Fronek A, Linhart J, Prerovsky I. Measurement of blood flow in the femoral artery in man at rest and during exercise by local thermo-dilution. Circulation. 1964; 30; 86-9.
• Chatterjee K. The Swan-Ganz catheters: past, present, and future. A viewpoint. Circulation. 2009; 119; 147-52.
• Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJ. Measurement of coronary sinus blood flow by continuous thermo-dilution in man. Circulation. 1971; 44; 181-95.
• Ganz W, Buchbinder N, Marcus H, Mondkar A, Maddahi J, Charuzi Y, et al. Intracoronary thrombolysis in evolving myocardial infarction. Am Heart J. 1981; 101; 4-13.

Controversies

He claimed that the “sail – boat” idea was apocryphal and that the use of the balloon was driven by both the need to float the catheter and, most important, to cover the sharp tip of the catheter to reduce the mechanical irritation to the endocardium that caused arrhythmia during passage.⁶

References

1. Maltby R. Notable Names in Anaesthesia. The Choir Press; pp 209-213 (2013)
2. Nickson C. History of the Pulmonary Artery Catheter. LITFL
3. Bateman BT, Alston TA. Commonly used eponyms in anesthesia. J Clin Anesth. 2009 Feb; 21(1); 67-71
4. Swan HJ, Ganz W, Forrester J, Marcus H, Diamond G, Chonette D. Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter. N Engl J Med. 1970 Aug 27;283(9); 447-51.
5. Ganz V, Hlavova A, Fronek A, Linhart J, Prerovsky I. Measurement of blood flow in the femoral artery in man at rest and during exercise by local thermo-dilution. Circulation. 1964; 30; 86-9.
6. Ganz Y, Ganz P. William Ganz and His Legacy. Annals of Internal Medicine. 2019 May; 170(10); 734-735
7. Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJ. Measurement of coronary sinus blood flow by continuous thermo-dilution in man. Circulation. 1971; 44; 181-95.
8. Ganz W, Buchbinder N, Marcus H, Mondkar A, Maddahi J, Charuzi Y, et al. Intracoronary thrombolysis in evolving myocardial infarction. Am Heart J. 1981; 101; 4-13.