Month January 2019
CCC Critical Care Compendium 680

Hilar enlargement on chest x-ray

Hilar enlargement reflects one of 4 types of processes: Lymphadenopathy and tumors; Pulmonary venous hypertension; Pulmonary arterial hypertension; or Increased pulmonary blood flow

CCC Critical Care Compendium 680

Upper Gastrointestinal Haemorrhage DDx

Upper gastrointestinal haemorrhage is classically bleeding from above the ligament of Trietz (the suspensory muscle of duodenum that connects to the diaphragm), can is characterised by haemetemesis and melaena.

CCC Critical Care Compendium 680

Bulbar and pseudobulbar palsy

A bulbar palsy is a lower motor neuron lesion of cranial nerves IX, X and XII. A pseudobulbar palsy is an upper motor neuron lesion of cranial nerves IX, X and XII.

CCC Critical Care compendium 340

Neutropaenic Sepsis

Febrile neutropaenia (or neutropaenic fever) is defined as: a single temperature measurement >=38.5C, or a sustained temperature >=38C for more than 1 hour; in a patient with a decreased absolute neutrophil count (ANC) of either <0.5 x 109/L, or <1 x 109/L with a predicted nadir of <0.5 x 109/L over the subsequent 48h

CCC Critical Care compendium 340

Hepatorenal Syndrome

Hepatorenal Syndrome = profound oliguria and Na+ retention in the setting of severe liver dysfunction (cirrhosis or fulminant liver failure); usually fatal unless liver transplant performed. RRT can prevent advancement of condition

CCC Critical Care compendium 340

Surviving Sepsis Campaign Guidelines 2012

Reviewed and revised 8 January 2016 OVERVIEW The Surviving Sepsis Campaign (SSC) is a joint collaboration of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine that seeks to reduce mortality from severe sepsis and septic shock…

CCC Critical Care compendium 340

Sepsis Pathophysiology

OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK =…

CCC Critical Care compendium 340

Corticosteroid Therapy for Shock

Corticosteroids are widely used in patients with refractory septic shock, as well as other selected causes of shock. Despite numerous trials, the role of corticosteroids in septic shock remains a controversial issue... still!

CCC Critical Care compendium 340

Pharmacokinetics and ECMO

ECMO support has potential implications for pharmacotherapy in the critically ill, the significance of which are poorly defined; Pharmacokinetic effects of ECMO vary with different drugs and drug characteristics